Product Information
67443-1-PBS targets MTH1 as part of a matched antibody pair:
MP50783-2: 67443-1-PBS capture and 67443-4-PBS detection (validated in Cytometric bead array)
Unconjugated mouse monoclonal antibody pair in PBS only (BSA and azide free) storage buffer at a concentration of 1 mg/mL, ready for conjugation.
This conjugation ready format makes antibodies ideal for use in many applications including: ELISAs, multiplex assays requiring matched pairs, mass cytometry, and multiplex imaging applications.Antibody use should be optimized by the end user for each application and assay.
Tested Reactivity | human, mouse |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Immunogen | MTH1 fusion protein Ag9802 Predict reactive species |
Full Name | nudix (nucleoside diphosphate linked moiety X)-type motif 1 |
Calculated Molecular Weight | 179aa,20 kDa; 197aa,23 kDa |
Observed Molecular Weight | 19 kDa |
GenBank Accession Number | BC014618 |
Gene Symbol | MTH1 |
Gene ID (NCBI) | 4521 |
RRID | AB_2882678 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
UNIPROT ID | P36639 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
MTH1, also known as NUDT1 or 8-Oxo-dGTPase, is an important repair enzyme that prevents oxidative stress-induced DNA damage through hydrolyzing mutagenic 8-oxo-dGTP into 8-oxo-dGMP. MTH1 is expressed in postmitotic neurons as well as in proliferative tissues, and it is localized both in the mitochondria and nucleus. MTH1 might be a useful marker of oxidative stress and its level increased upon oxidative stress. Increased expression of MTH1 were also found in various cancer tissues and neurodegenerative diseases.