MOV10 Polyclonal antibody, PBS Only

• Featured Product
• KD/KO Validated

MOV10 Polyclonal Antibody for WB, IHC, IF/ICC, IP, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IHC, IF/ICC, IP, Indirect ELISA

Conjugate

Unconjugated

Cat no : 10370-1-PBS

Synonyms

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Validation Data Gallery

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  WB analysis using 10370-1-AP (same clone as 10370-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 10370-1-AP (MOV10 antibody) at dilution of 1:8000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 10370-1-PBS in a different storage buffer formulation.

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  WB analysis of HepG2 using 10370-1-AP (same clone as 10370-1-PBS)

  HepG2 cells were subjected to SDS PAGE followed by western blot with 10370-1-AP (MOV10 antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 10370-1-PBS in a different storage buffer formulation.

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  WB analysis of human liver using 10370-1-AP (same clone as 10370-1-PBS)

  human liver tissue were subjected to SDS PAGE followed by western blot with 10370-1-AP (MOV10 antibody) at dilution of 1:0 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 10370-1-PBS in a different storage buffer formulation.

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  IP experiment of Hepg2 using 10370-1-AP (same clone as 10370-1-PBS)

  IP result of anti-MOV10 (IP:10370-1-AP, 4ug; Detection:10370-1-AP 1:300) with Hepg2 cells lysate 3000 ug. This data was developed using the same antibody clone with 10370-1-PBS in a different storage buffer formulation.

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  IHC staining of human prostate hyperplasia using 10370-1-AP (same clone as 10370-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human prostate hyperplasia tissue slide using 10370-1-AP (MOV10 antibody) at dilution of 1:200 (under 10x lens). This data was developed using the same antibody clone with 10370-1-PBS in a different storage buffer formulation.

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  IHC staining of human prostate hyperplasia using 10370-1-AP (same clone as 10370-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human prostate hyperplasia tissue slide using 10370-1-AP (MOV10 antibody) at dilution of 1:200 (under 40x lens). This data was developed using the same antibody clone with 10370-1-PBS in a different storage buffer formulation.

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  IF Staining of HepG2 using 10370-1-AP (same clone as 10370-1-PBS)

  Immunofluorescent analysis of (4% PFA) fixed HepG2 cells using MOV10 antibody (10370-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). This data was developed using the same antibody clone with 10370-1-PBS in a different storage buffer formulation.

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Product Information

10370-1-PBS targets MOV10 in WB, IHC, IF/ICC, IP, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

• Tested Reactivity: human, mouse, rat
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: MOV10 fusion protein Ag0384
• Full Name: Mov10, Moloney leukemia virus 10, homolog (mouse)
• Calculated Molecular Weight: 114 kDa
• Observed Molecular Weight: 110-115 kDa
• GenBank Accession Number: BC002548
• Gene Symbol: MOV10
• Gene ID (NCBI): 4343
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• Storage Buffer: PBS Only
• Storage Conditions: Store at -80°C.

Background Information

MOV10, also named as KIAA1631, belongs to the DNA2/NAM7 helicase family and SDE3 subfamily. It is required for RNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Human MOV10 may regulate a wide range of RNA viruses and could also control the retrotransposition of endogenous retroelements in mammals(PMID:22727223). MOV10 has a broad antiretroviral activity that can target a wide range of retroviruses, and it could be actively involved in host defense against retroviral infection. MOV10 can potently inhibit HIV-1 replication at multiple stages(PMID:20215113). It is involved in the progression of telomerase-catalyzing reaction via the interaction of telomerase protein and telomere DNA.