METTL6 Recombinant antibody, PBS Only
METTL6 Uni-rAbTM Recombinant Antibody for WB, Indirect ELISA
Host / Isotype
Rabbit / IgG
Reactivity
human
Applications
WB, Indirect ELISA
Conjugate
Unconjugated
CloneNo.
241482F12
Cat no : 84209-4-PBS
Synonyms
Validation Data Gallery
Product Information
The immunogen of 84209-4-PBS is METTL6 Fusion Protein expressed in E. coli.
Tested Reactivity | human |
Host / Isotype | Rabbit / IgG |
Class | Recombinant |
Type | Antibody |
Immunogen | METTL6 fusion protein Ag9714 |
Full Name | methyltransferase like 6 |
Calculated Molecular Weight | 255 aa, 30 kDa |
Observed Molecular Weight | 30-32 kDa |
GenBank Accession Number | BC022400 |
Gene Symbol | METTL6 |
Gene ID (NCBI) | 131965 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purfication |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
Methyltransferase-like protein 6 (METTL6) belongs to the METL family. METTL6 is as a crucial regulator of tumor cell growth, and METTL6 is a bona fide transfer RNA (tRNA) methyltransferase, catalyzing the formation of 3-methylcytidine at C32 of specific serine tRNA isoacceptors (PMID:32923617). METTL6 is a member of the RNA methyltransferase family that has been identified in many cancers. The mRNA expression levels of METTL6 were significantly upregulated in HCC tumor tissues compared to that in adjacent non-tumor tissues. CRISPR/Cas9 mediated knockout of METTL6 in hepatocellular carcinoma cell lines remarkably inhibited colony formation, cell proliferation, cell migration, cell invasion and cell attachment ability (PMID:34913069).