TAB2 Recombinant antibody

TAB2 Uni-rAb^TM Recombinant Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, ELISA

Conjugate

Unconjugated

CloneNo.

230118F1

Cat no : 82948-5-RR

Synonyms

MAP3K7IP2, TAB-2, TAB 2, Mitogen-activated protein kinase kinase kinase 7-interacting protein 2, KIAA0733

---

Validation Data Gallery

• 

  WB analysis using 82948-5-RR

  Various lysates were subjected to SDS PAGE followed by western blot with 82948-5-RR (MAP3K7IP2 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours.

• 

  Affinity and Kinetic Characterization of 82948-5-RR

  Biolayer interferometry (BLl) kinetic assays of 82948-5-RR against Human TAB2 were performed. The affinity constant is 65.2 pM.

---

Tested Applications

• Positive WB detected in: HepG2 cells, HEK-293T cells, L02 cells, Raji cells, RAW 264.7 cells

Recommended dilution

• Western Blot (WB): WB : 1:2000-1:10000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

82948-5-RR targets TAB2 in WB, ELISA applications and shows reactivity with human, mouse samples.

• Tested Reactivity: human, mouse
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen: TAB2 fusion protein Ag5742
• Full Name: mitogen-activated protein kinase kinase kinase 7 interacting protein 2
• Calculated Molecular Weight: 76 kDa
• Observed Molecular Weight: 77 kDa
• GenBank Accession Number: BC035910
• Gene Symbol: MAP3K7IP2
• Gene ID (NCBI): 23118
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

Tab2 has a role in the inflammatory signal transduction pathway and is involved in the reversal of NCoR-dependent and NFkB- or APP-mediated gene repression and androgen antagonist response. Besides, it is identified as a cofactor for ERBB4 to assemble NCoR corepressor complex in response to neuregulin [PMID:16469706]. It also functions as an adaptor that links TAK1 and TRAF6 in response to interleukin-1β (IL-1β) or tumour necrosis factor-α (TNF-α), and thereby mediates TAK1 activation [PMID:11460167].