- Featured Product
- KD/KO Validated
LRPPRC Monoclonal antibody, PBS Only
LRPPRC Monoclonal Antibody for WB, IHC, IF/ICC, ELISA
Host / Isotype
Mouse / IgG2b
Reactivity
Human
Applications
WB, IHC, IF/ICC, ELISA
Conjugate
Unconjugated
CloneNo.
3H7E1
Cat no : 67679-1-PBS
Synonyms
Validation Data Gallery
Product Information
67679-1-PBS targets LRPPRC in WB, IHC, IF/ICC, ELISA applications and shows reactivity with Human samples.
Tested Reactivity | Human |
Host / Isotype | Mouse / IgG2b |
Class | Monoclonal |
Type | Antibody |
Immunogen | LRPPRC fusion protein Ag30261 |
Full Name | leucine-rich PPR-motif containing |
Calculated Molecular Weight | 1394 aa, 158 kDa |
Observed Molecular Weight | 130 kDa |
GenBank Accession Number | BC050311 |
Gene Symbol | LRPPRC |
Gene ID (NCBI) | 10128 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
Storage Buffer | PBS only |
Storage Conditions | Store at -80°C. |
Background Information
LRPPRC (also called LRP130 or GP130) is a 130-kDa RNA-binding protein of the pentatricopeptide repeat family. LRPPRC localizes primarily to the mitochondria where it binds to poly(A) mRNA. It plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. LRPPRC has also been shown to regulate nuclear gene transcription and to bind specific RNA molecules in both the nucleus and the cytoplasm. Mutations in LRPPRC gene are associated with the French-Canadian type of Leigh syndrome.