Validation Data Gallery
|Positive WB detected in||A375 cells, human brain tissue, C2C12 cells|
|Positive IP detected in||A375 cells|
|Positive IF detected in||Hela cells, C6 cells, HepG2 cells|
|Positive FC detected in||Jurkat cells|
|Western Blot (WB)||WB : 1:1000-1:4000|
|Immunoprecipitation (IP)||IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB|
|Immunofluorescence (IF)||IF : 1:25-1:100|
|Sample-dependent, check data in validation data gallery|
12398-1-AP targets LBR in WB, IP, IF, FC, ELISA applications and shows reactivity with human, mouse, rat samples.
|Tested Reactivity||human, mouse, rat|
|Cited Reactivity||human, mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||LBR fusion protein Ag3088|
|Full Name||lamin B receptor|
|Calculated molecular weight||615 aa, 71 kDa|
|Observed molecular weight||58 kDa|
|GenBank accession number||BC020079|
|Gene ID (NCBI)||3930|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
Lamin-B receptor (LBR) belongs to the ERG4/ERG24 family. LBR is a 58-kDa integral protein of the nuclear envelope inner membrane and anchors the lamina and the heterochromatin to the inner nuclear membrane. LBR may mediate the interaction between chromatin and lamin B. Mutations of the LBR gene have been associated with autosomal recessive HEM/Greenberg skeletal dysplasia.
|Product Specific Protocols|
|WB protocol for LBR antibody 12398-1-AP||Download protocol|
|IF protocol for LBR antibody 12398-1-AP||Download protocol|
|IP protocol for LBR antibody 12398-1-AP||Download protocol|
|FC protocol for LBR antibody 12398-1-AP||Download protocol|
|Click here to view our Standard Protocols|
A common pathomechanism in GMAP-210- and LBR-related diseases.
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