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Kir6.2 Polyclonal antibody, PBS Only

Kir6.2 Polyclonal Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

Cat no : 16920-1-PBS

Synonyms

Validation Data Gallery

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  • Western Blot (WB) analysis of rat heart tissue using Kir6.2 Polyclonal antibody (16920-1-AP)

    WB analysis of rat heart using 16920-1-AP (same clone as 16920-1-PBS)

    rat heart tissue were subjected to SDS PAGE followed by western blot with 16920-1-AP (Kir6.2 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 16920-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of rat skeletal muscle tissue using Kir6.2 Polyclonal antibody (16920-1-AP)

    WB analysis of rat skeletal muscle using 16920-1-AP (same clone as 16920-1-PBS)

    rat skeletal muscle tissue were subjected to SDS PAGE followed by western blot with 16920-1-AP (Kir6.2 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 16920-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of HepG2 cells using Kir6.2 Polyclonal antibody (16920-1-AP)

    WB analysis of HepG2 using 16920-1-AP (same clone as 16920-1-PBS)

    HepG2 cells were subjected to SDS PAGE followed by western blot with 16920-1-AP (KCNJ11 antibody) at dilution of 1:400 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 16920-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of human heart tissue using Kir6.2 Polyclonal antibody (16920-1-AP)

    WB analysis of human heart using 16920-1-AP (same clone as 16920-1-PBS)

    human heart tissue were subjected to SDS PAGE followed by western blot with 16920-1-AP (KCNJ11 antibody) at dilution of 1:200 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 16920-1-PBS in a different storage buffer formulation.

Product Information

16920-1-PBS targets Kir6.2 in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen Kir6.2 fusion protein Ag10262
Full Name potassium inwardly-rectifying channel, subfamily J, member 11
Calculated Molecular Weight 390 aa, 44 kDa
Observed Molecular Weight 48 kDa
GenBank Accession NumberBC064497
Gene Symbol Kir6.2
Gene ID (NCBI) 3767
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

Kir6.2 (also known as BIR or IKATP), encoded by the KCNJ11 gene, is the pore-forming unit of the ATP-sensitive K+ channel, an inward-rectifier potassium ion channel. Kir6.2 is controlled by G-proteins and is found associated with the sulfonylurea receptor (SUR) to constitute the ATP-sensitive K+ channel. The KCNJ11 gene is located at 11p15.1 and has no intron. Mutations in KCNJ11 are a cause of familial PHHI, an autosomal recessive disorder characterized by unregulated ins secretion. Defects in KCNJ11 may also contribute to autosomal dominant non-ins-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM).