KU70,XRCC6 Monoclonal antibody, PBS Only
KU70,XRCC6 Monoclonal Antibody for WB, IHC, IF/ICC, IF-P, FC (Intra), Indirect ELISA
Host / Isotype
Mouse / IgG1
Reactivity
human, mouse, rat
Applications
WB, IHC, IF/ICC, IF-P, FC (Intra), Indirect ELISA
Conjugate
Unconjugated
CloneNo.
3C12D9
Cat no : 66607-1-PBS
Synonyms
Validation Data Gallery
Product Information
66607-1-PBS targets KU70,XRCC6 in WB, IHC, IF/ICC, IF-P, FC (Intra), Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
Tested Reactivity | human, mouse, rat |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Immunogen | KU70,XRCC6 fusion protein Ag21301 |
Full Name | X-ray repair complementing defective repair in Chinese hamster cells 6 |
Calculated Molecular Weight | 75 kDa |
Observed Molecular Weight | 70 kDa |
GenBank Accession Number | BC008343 |
Gene Symbol | KU70 |
Gene ID (NCBI) | 2547 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
X-ray repair cross-complementing protein 6(XRCC6)gene encodes subunit p70 of the p70/p80 autoantigen which has a role in DNA repair or transposition. DNA helicase II complex binds preferentially to fork-like ends of double-standed DNA in a cell cycle-dependent manner, which may be mediated by XRCC6. XRCC6/5 can form a heterdimer, which function as a regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA, and also it can stablize broken DNA ends and bringing them together. Otherwise, XRCC5/6 heterdimer together with APEX1 can negatively regulate of transcription.