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KLF6 Monoclonal antibody, PBS Only

KLF6 Monoclonal Antibody for WB, ELISA

Host / Isotype

Mouse / IgG1

Reactivity

Human, mouse

Applications

WB, ELISA

Conjugate

Unconjugated

CloneNo.

2F8B3

Cat no : 67297-1-PBS

Synonyms

B cell derived protein 1, COPEB, CPBP, DKFZp686N0199, GBF, KLF6, Krueppel like factor 6, Kruppel like factor 6, PAC1, Proto oncogene BCD1, ST12, Transcription factor Zf9, ZF9

Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using KLF6 Monoclonal antibody (67297-1-Ig)

    WB analysis using 67297-1-Ig (same clone as 67297-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 67297-1-Ig (KLF6 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67297-1-PBS in a different storage buffer formulation.

Product Information

67297-1-PBS targets KLF6 in WB, ELISA applications and shows reactivity with Human, mouse samples.

Tested Reactivity Human, mouse
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Immunogen KLF6 fusion protein Ag6859
Full Name Kruppel-like factor 6
Calculated Molecular Weight 32 kDa
Observed Molecular Weight 32-42 kDa
GenBank Accession NumberBC000311
Gene Symbol KLF6
Gene ID (NCBI) 1316
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
Storage Buffer PBS only
Storage ConditionsStore at -80°C.

Background Information

KLF6(krupple-like factor 6) is a zinc finger transcription factor and tumor suppressor with biological activities and transcriptional targets in growing range. It is highly expressed in placenta followed by spleen, thymus, prostate, testis, small intestine and colon. One key target gene of KLF6 in endoglin, which is a homodimeric cell membrane glycoprotein and TGF-β auxiliary receptor, owns a pro-angiogenic role in endothelial cells and is also involved in malignant progression. Also KLF6 induces apoptosis in prostate cancer cells through upregulation of ATF3. KLF6 was normal detected as a 46kDa protein, which is larger than translation product(32kDa), because of post-translational modification including both phosphorylation and glycosylation. This antibody raise against the full length of KLF6 gene of human origin, and can recognize both of KLF6, included KLF6(~32kDa), p-KLF6(~35-46kDa). Otherwise, there may be a non-specific band(50kDa) showed in detection