FITC Plus Anti-Human KIM-1/HAVCR1 Rabbit Recombinant Antibody

• 

  FC experiment of HuH-7 using FITC-98238

  1x10^6 HuH-7 cells (left) or HEK293T cells (right) were stained with 0.25 ug FITC Plus Anti-Human KIM-1/HAVCR1 Rabbit RecAb (FITC-98238, Clone: 242001E8) (red), or FITC Plus Rabbit IgG Isotype Control Recombinant Antibody (FITC-98136, Clone: 240953C9) (blue). Cells were not fixed.

KIM-1/HAVCR1 Uni-rAb^TM Recombinant Antibody for FC

Cat No. FITC-98238

Clone No.242001E8

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

Synonyms

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Tested Applications

• Positive FC detected in: HuH-7 cells

Recommended dilution

Application	Dilution
This reagent has been pre-titrated and tested for flow cytometric analysis. The suggested use of this reagent is N/A per 10^6 cells in a 100 µl suspension or N/A per 100 µl of whole blood.
Sample-dependent, Check data in validation data gallery.

Product Information

FITC-98238 targets KIM-1/HAVCR1 in applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen: Recombinant protein
• Full Name: hepatitis A virus cellular receptor 1
• Calculated Molecular Weight: 39kDa
• GenBank Accession Number: NM_001173393.3
• Gene Symbol: HAVCR1
• Gene ID (NCBI): 26762
• Conjugate: FITC Plus Fluorescent Dye
• Excitation/Emission Maxima Wavelengths: 495 nm / 524 nm
• Form: Liquid
• Purification Method: Protein A purification
• UNIPROT ID: Q96D42
• Storage Buffer: PBS with 0.09% sodium azide and 0.5% BSA.
• Storage Conditions: Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.

Background Information

Kidney injury molecule 1 (KIM-1), also known as Hepatitis A virus cellular receptor 1 (HAVCR1), CD365, or T-cell immunoglobulin and mucin domain 1 (TIM-1), is a class I integral membrane glycoprotein, with an ectodomain containing Ig-like domain and a mucin domain. KIM-1 acts as a membrane receptor for hepatitis A virus (HAV) (PMID: 9658108; 8861957). KIM-1 provides a costimulatory signal for T cell activation and inhibits the development of peripheral tolerance (PMID: 16284246; 15793575). KIM-1 may be involved in the regulation of asthma and allergic diseases (PMID: 14534576). It has been reported that KIM-1 is shed into urine after acute kidney damage and is a marker of renal tubular injury (PMID: 14600030).