ISLR2 Recombinant antibody, PBS Only

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  WB analysis using 84076-3-RR (same clone as 84076-3-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 84076-3-RR (ISLR2 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84076-3-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 84076-3-RR

  Biolayer interferometry (BLl) kinetic assays of 84076-3-RR against Human ISLR2 were performed. The affinity constant is below 1 pM.

ISLR2 {ptg:Brand} Recombinant Antibody for WB, Indirect ELISA

Cat No. 84076-3-PBS

Clone No.241227D6

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, Indirect ELISA

Synonyms

LINX, Leucine-rich repeat domain and immunoglobulin domain-containing axon extension protein, KIAA1465, Immunoglobulin superfamily containing leucine-rich repeat protein 2, 241227D6

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Product Information

84076-3-PBS targets ISLR2 in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

• Tested Reactivity: human, mouse, rat
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen: ISLR2 fusion protein Ag20505
• Full Name: immunoglobulin superfamily containing leucine-rich repeat 2
• Calculated Molecular Weight: 745 aa, 79 kDa
• Observed Molecular Weight: 79 kDa, 130 kDa
• GenBank Accession Number: BC152429
• Gene Symbol: ISLR2
• Gene ID (NCBI): 57611
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purfication
• UNIPROT ID: Q6UXK2
• Storage Buffer: PBS only , pH 7.3
• Storage Conditions: Store at -80°C.

Background Information

ISLR2 (immunoglobulin superfamily containing leucine rich repeat 2), also known as LINX. It is expected to be located in cell membrane and the protein is mainly expressed in brain and testis. While the first knockout mouse had impaired development of the internal capsule and no hydrocephalus, a much more recent independent knockout mouse was shown to additionally have severe hydrocephalus. Although the mechanism remains unclear, it may be related to the role of ISLR2 in reorganizing the cytoskeleton of developing neurons (PMID: 30483960). The calculated molecular weight of ISLR2 is 79 kDa, this target has phosphorylation modification and glycosylation modification. And the 130 kDa band is glycosylated (PMID: 29739947).