IRE1; ERN1 Polyclonal antibody, PBS Only
IRE1; ERN1 Polyclonal Antibody for WB, Indirect ELISA
Host / Isotype
Rabbit / IgG
Reactivity
human
Applications
WB, Indirect ELISA
Conjugate
Unconjugated
Cat no : 28164-1-PBS
Synonyms
Validation Data Gallery
Product Information
28164-1-PBS targets IRE1; ERN1 in WB, Indirect ELISA applications and shows reactivity with human samples.
Tested Reactivity | human |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Immunogen | IRE1; ERN1 fusion protein Ag27375 |
Full Name | endoplasmic reticulum to nucleus signaling 1 |
Calculated Molecular Weight | 977 aa, 110 kDa |
Observed Molecular Weight | 130 kDa |
GenBank Accession Number | BC130405 |
Gene Symbol | IRE1 |
Gene ID (NCBI) | 2081 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Antigen affinity purification |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
Inositol-requiring enzyme 1 (IRE1) is an ER transmembrane sensor that activates the UPR to maintain the ER and cellular function. Although mammalian IRE1 promotes cell survival, it can initiate apoptosis via decay of antiapoptotic miRNAs. IRE1 contains a ribonuclease domain in its cytoplasmic region which initiates splicing reaction by direct cleavage of XBP1 mRNA at the two stem loop structures. IRE1 plays instrumental protumoral roles in several cancers, and high IRE1 activity has been associated with poorer prognoses. (PMID: 23880584, PMID: 32861679, PMID: 31875595)