IRE1; ERN1 Polyclonal antibody, PBS Only

IRE1; ERN1 Polyclonal Antibody for WB, Indirect ELISA
Cat No. 28164-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Formulation:  PBS Only
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

Freight/Packing: -

Quantity

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Product Information

28164-1-PBS targets IRE1; ERN1 in WB, Indirect ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen IRE1; ERN1 fusion protein Ag27375 Predict reactive species
Full Name endoplasmic reticulum to nucleus signaling 1
Calculated Molecular Weight 977 aa, 110 kDa
Observed Molecular Weight 130 kDa
GenBank Accession NumberBC130405
Gene Symbol IRE1
Gene ID (NCBI) 2081
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDO75460
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

Inositol-requiring enzyme 1 (IRE1) is an ER transmembrane sensor that activates the UPR to maintain the ER and cellular function. Although mammalian IRE1 promotes cell survival, it can initiate apoptosis via decay of antiapoptotic miRNAs. IRE1 contains a ribonuclease domain in its cytoplasmic region which initiates splicing reaction by direct cleavage of XBP1 mRNA at the two stem loop structures. IRE1 plays instrumental protumoral roles in several cancers, and high IRE1 activity has been associated with poorer prognoses. (PMID: 23880584, PMID: 32861679, PMID: 31875595)

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