IL-7 Monoclonal antibody

IL-7 Monoclonal Antibody for ELISA

Host / Isotype

Mouse / IgG2b

Reactivity

human

Applications

WB, IF, ELISA

Conjugate

Unconjugated

Publications

3

CloneNo.

5D5G7

Cat no : 60206-1-Ig

Synonyms

IL 7, IL7, IL-7, interleukin 7

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Validation Data Gallery

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Published Applications

• WB: See 2 publications below
• IF: See 1 publications below

Product Information

The immunogen of 60206-1-Ig is IL-7 Fusion Protein expressed in E. coli.

• Tested Reactivity: human
• Cited Reactivity: human
• Host / Isotype: Mouse / IgG2b
• Class: Monoclonal
• Type: Antibody
• Affinity:
  K_D=7.40 x 10^-10M
  K_Off=7.82 x 10^-6M
  K_On=1.06 x 10^4M
• Immunogen: IL-7 fusion protein Ag16314
• Full Name: interleukin 7
• Calculated Molecular Weight: 20 kDa
• GenBank Accession Number: BC047698
• Gene Symbol: IL-7
• Gene ID (NCBI): 3574
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

Interleukin-7 (IL7) is a cytokine mportant for B and T cell development. IL7 plays an active role in the development, survival, maintaining and restoring homeostasis of mature T lymphocytes. It is also a key regulator of the commitment, survival, proliferation and maturation of B cells during development. Furthermore, IL7 can improve the antiviral function and expansion of natural killer (NK) cells and regulate the development and differentiation of dendritic cells. IL7 has also been reported as a regulator of the development of central nervous system and myogenesis and skeletal muscle cell migration.

Publications

Species	Application	Title
human	WB	Sci Rep; Anti-inflammatory effects of α-MSH through p-CREB expression in sarcoidosis like granuloma model.; Authors - Chongxu Zhang
human	WB,IF	Sci Rep; Interleukin-7 Contributes to the Invasiveness of Prostate Cancer Cells by Promoting Epithelial-Mesenchymal Transition.; Authors - Min A Seol
		Free Radic Biol Med; Oxidative stress-induced IL-15 transtrans-presentation in keratinocytes contributes to CD8+ T cells activation via JAK-STAT pathway in vitiligo.; Authors - Xuguang Chen