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IL-7 Monoclonal antibody, PBS Only (Detector)

IL-7 Monoclonal Antibody for Cytometric bead array, Indirect ELISA

Host / Isotype

Mouse / IgG2b

Reactivity

human

Applications

Cytometric bead array, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

5D5G7

Cat no : 60206-1-PBS

Synonyms

IL7, Interleukin-7, interleukin 7, IL 7, 5D5G7

Validation Data Gallery

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  • Cytometric bead array standard curve of MP50135-1

    Cytometric bead array standard curve of MP50135-1

    Cytometric bead array standard curve of MP50135-1, IL7 Monoclonal Matched Antibody Pair, PBS Only. Capture antibody: 60206-2-PBS. Detection antibody: 60206-1-PBS. Standard:Ag16314. Range: 3.125-100 ng/mL.

Product Information

60206-1-PBS targets IL-7 as part of a matched antibody pair:

MP50135-1: 60206-2-PBS capture and 60206-1-PBS detection (validated in Cytometric bead array)

Unconjugated mouse monoclonal antibody pair in PBS only (BSA and azide free) storage buffer at a concentration of 1 mg/mL, ready for conjugation.

This conjugation ready format makes antibodies ideal for use in many applications including: ELISAs, multiplex assays requiring matched pairs, mass cytometry, and multiplex imaging applications.Antibody use should be optimized by the end user for each application and assay.

Tested Reactivity human
Host / Isotype Mouse / IgG2b
Class Monoclonal
Type Antibody
Affinity
KD=7.40 x 10-10M
KOff=7.82 x 10-6M
KOn=1.06 x 104M
Immunogen IL-7 fusion protein Ag16314
Full Name interleukin 7
Calculated Molecular Weight 20 kDa
GenBank Accession NumberBC047698
Gene Symbol IL-7
Gene ID (NCBI) 3574
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

IL-7 is one of the members of IL-2 superfamily. IL-7 is a hematopoietic growth factor secreted by stromal cells in the bone marrow and thymus. It is also produced by keratinocytes, dendritic cells, hepatocytes, neurons, and epithelial cells, but is not produced by normal lymphocytes. IL7 plays an active role in the development, survival, maintaining and restoring homeostasis of mature T lymphocytes. It is also a key regulator of the commitment, survival, proliferation and maturation of B cells during development. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can be a potent inducer of proinflammatory cytokines and chemokines which may defend against the infection, but may also mediate destructive lung injury. Elevated serum IL7 levels, together with several other circulating cytokines and chemokines, has been found to be associated with the severity of Coronavirus Disease 19 (COVID-19).