Anti-Human IL-23R Rabbit Recombinant Antibody

• 

  FC experiment of Transfected HEK-293T using 98180-1-RR

  1x10^6 HEK-293T cells or IL-23R-transfected HEK-293T cells were surface stained with 0.25 ug Anti-Human IL-23R Rabbit Recombinant Antibody (98180-1-RR, Clone: 240905B5) and Multi-rAb CoraLite ® Plus 647-Goat Anti-Rabbit Recombinant Secondary Antibody (H+L) (RGAR005). Cells were not fixed.

• 

  FC experiment of Transfected HEK-293T using 98180-1-RR

  1x10^6 HEK-293T cells (left) or IL-23R-transfected HEK-293T cells (right) were surface stained with 0.25 ug Anti-Human IL-23R Rabbit Recombinant Antibody (98180-1-RR, Clone: 240905B5) (red) or Isotype Control (blue), and Multi-rAb CoraLite ® Plus 647-Goat Anti-Rabbit Recombinant Secondary Antibody (H+L) (RGAR005). Cells were not fixed.

• 

  Affinity and Kinetic Characterization of 98180-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98180-1-RR against Human IL-23R were performed. The affinity constant is 2.83 nM.

IL-23R {ptg:Brand} Recombinant Antibody for FC

Cat No. 98180-1-RR

Clone No.240905B5

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

FC

Synonyms

IL23R, interleukin 23 receptor, IL-23 receptor, IL 23R, IL 23 receptor

---

Tested Applications

• Positive FC detected in: Transfected HEK-293T cells

Recommended dilution

Application	Dilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

98180-1-RR targets IL-23R in FC applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen: Recombinant protein
• Full Name: interleukin 23 receptor
• Calculated Molecular Weight: 72 kDa
• GenBank Accession Number: NM_144701.3
• Gene Symbol: IL-23R
• Gene ID (NCBI): 149233
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purfication
• UNIPROT ID: Q5VWK5-1
• Storage Buffer: PBS with 0.09% sodium azide , pH 7.3
• Storage Conditions: Store at 2 - 8°C. Stable for one year after shipment.

Background Information

Interleukin-23 receptor (IL-23R) is a type I cytokine receptor that plays a critical role in immune responses and inflammation. It forms a receptor complex with IL-12Rβ1 and is activated by the cytokine IL-23, which is primarily produced by dendritic cells and activated macrophages (PMID: 39796684). The genetic and epigenetic interactions in the IL-23R/IL-17 axis are associated with elevated expression of IL-17 and inflammatory bowel disease (IBD) pathogenesis (PMID: 21672939).