IL-23 p19 Monoclonal antibody, PBS Only

IL-23 p19 Monoclonal Antibody for IHC, Indirect ELISA

Host / Isotype

Mouse / IgG1

Reactivity

human

Applications

IHC, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

1D5D3

Cat no : 66196-1-PBS

Synonyms

IL23A, IL-23 subunit alpha, IL 23p19, IL 23A, IL 23 subunit alpha

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Validation Data Gallery

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  IHC staining of human stomach cancer using 66196-1-Ig (same clone as 66196-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human stomach cancer tissue slide using 66196-1-Ig (IL-23A antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66196-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human stomach cancer using 66196-1-Ig (same clone as 66196-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human stomach cancer tissue slide using 66196-1-Ig (IL-23A antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66196-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human pancreas using 66196-1-Ig (same clone as 66196-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human pancreas tissue slide using 66196-1-Ig (IL23A Antibody) at dilution of 1:50 (under 40x lens). This data was developed using the same antibody clone with 66196-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human pancreas using 66196-1-Ig (same clone as 66196-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human pancreas tissue slide using 66196-1-Ig (IL23A Antibody) at dilution of 1:50 (under 40x lens). This data was developed using the same antibody clone with 66196-1-PBS in a different storage buffer formulation.

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Product Information

66196-1-PBS targets IL-23 p19 in IHC, Indirect ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Mouse / IgG1
• Class: Monoclonal
• Type: Antibody
• Immunogen: IL-23 p19 fusion protein Ag19406
• Full Name: interleukin 23, alpha subunit p19
• Calculated Molecular Weight: 189 aa, 21 kDa
• GenBank Accession Number: BC066268
• Gene Symbol: IL23A
• Gene ID (NCBI): 51561
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein G purification
• Storage Buffer: PBS Only
• Storage Conditions: Store at -80°C.

Background Information

Interleukin 23 (IL-23) is a member of the IL12 cytokine family and composed of two subunits, IL12p40 and IL23p19. It is produced by antigen presenting cells and has been shown to promote the production and survival of a distinct lineage of T-cells called TH17 cells. A functional receptor for IL-23 (the IL-23 receptor) has been identified and is composed of Il-12Rβ1 and IL-23R. IL-23 is expressed chiefly by the macrophages and DCs. The IL-23R is found on memory T cells, NKT cells, macrophages, DCs, and naive T cells upon activation by TGF-βand IL-6. The main biological effects of IL-23 identified initially consist of stimulation of antigen presentation by DCs, T cell differentiation to Th17 cells, and production of interferon-γ (IFN-γ). IL-23 acts also as an end-stage effector cytokine through direct action on macrophages.