Product Information
84532-4-PBS targets IL-1RA in WB, Indirect ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Recombinant |
| Type | Antibody |
| Immunogen | IL-1RA fusion protein Ag1277 Predict reactive species |
| Full Name | interleukin 1 receptor antagonist |
| Calculated Molecular Weight | 20 kDa |
| Observed Molecular Weight | 16-18 kDa |
| GenBank Accession Number | BC009745 |
| Gene Symbol | IL-1RA |
| Gene ID (NCBI) | 3557 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein A purfication |
| UNIPROT ID | P18510 |
| Storage Buffer | PBS Only |
| Storage Conditions | Store at -80°C. |
Background Information
Interleukin-1 receptor antagonist (IL-1RA) is a critical member of the IL-1 family of cytokines, which plays a significant role in modulating inflammatory responses. IL-1RA exists in two main forms: a secreted form (sIL-1Ra) and an intracellular form (icIL-1Ra). The secreted form is produced by various cells including monocytes, macrophages, neutrophils, and other cells, while the intracellular form is found in keratinocytes and other epithelial cells, as well as in monocytes and fibroblasts. IL-1RA is important in host defense against endotoxin-induced injury and is produced in numerous experimental animal models of disease, as well as in human autoimmune and chronic inflammatory diseases. It acts as an anti-inflammatory agent by maintaining the balance between pro-inflammatory IL-1α/β and its own anti-inflammatory effects.
