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Mouse IL-17A Recombinant antibody, PBS Only

IL-17A Uni-rAbTM Recombinant Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

mouse

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

230038B1

Cat no : 82905-1-PBS

Synonyms

Il17a, Interleukin17A, interleukin 17A, Il17, IL 17A

Validation Data Gallery

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  • Western Blot (WB) analysis of EL-4 cells using IL-17A Recombinant antibody (82905-1-RR)

    WB analysis of EL-4 using 82905-1-RR (same clone as 82905-1-PBS)

    PMA, Ionomycin and Brefeldin A treated EL-4 cells were subjected to SDS PAGE followed by western blot with 82905-1-RR (IL-17A antibody) at dilution of 1:2500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 82905-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 82905-1-RR

    Affinity and Kinetic Characterization of 82905-1-RR

    Biolayer interferometry (BLl) kinetic assays of 82905-1-RR against Mouse IL-17A were performed. The affinity constant is 7.59 nM.

Product Information

82905-1-PBS targets IL-17A in WB, Indirect ELISA applications and shows reactivity with mouse samples.

Tested Reactivity mouse
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen Recombinant protein
Full Name interleukin 17A
Calculated Molecular Weight17 kDa
Observed Molecular Weight14 kDa, 17 kDa
GenBank Accession NumberNM-010552
Gene Symbol Il17a
Gene ID (NCBI) 16171
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

IL17A, also named as IL-17, is a proinflammatory cytokine. IL-17, synthesized only by memory T cells and natural killer cells, has pleiotropic effects, mainly in the recruitment and activation of neutrophils. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The IL-17 receptor is a type I transmembrane protein, that is widely expressed on epithelial cells, fibroblasts, B and T cells, and monocytic cells. In psoriatic skin lesions, both Th17 cells and their downstream effector molecules, e.g. IL-17 and IL-22, are highly increased.