CoraLite® Plus 488-conjugated IL-12RB1 Monoclonal antibody
IL-12RB1 Monoclonal Antibody for
Host / Isotype
Mouse / IgG1
Reactivity
Human
Applications
Conjugate
CoraLite® Plus 488 Fluorescent Dye
CloneNo.
1E10E10
Cat no : CL488-66829
Synonyms
Validation Data Gallery
Recommended dilution
| Application | Dilution |
|---|---|
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
Product Information
CL488-66829 targets IL-12RB1 in applications and shows reactivity with Human samples.
| Tested Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Immunogen | IL-12RB1 fusion protein Ag6920 |
| Full Name | interleukin 12 receptor, beta 1 |
| Calculated Molecular Weight | 662 aa, 73 kDa |
| Observed Molecular Weight | 100-110 kDa |
| GenBank Accession Number | BC029121 |
| Gene Symbol | IL12RB1 |
| Gene ID (NCBI) | 3594 |
| Conjugate | CoraLite® Plus 488 Fluorescent Dye |
| Excitation/Emission Maxima Wavelengths | 493 nm / 522 nm |
| Form | Liquid |
| Purification Method | Protein G purification |
| Storage Buffer | PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3. |
| Storage Conditions | Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
Background Information
IL12RB1, also named as Interleukin-12 receptor subunit beta-1 or CD212, is a 662 amino acid protein, which contains 5 fibronectin type-III domains and belongs to the type I cytokine receptor family. Type 2 subfamily. IL12RB1 localizes in the membrane and functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade.
