Anti-Human IL-1 beta (2A7C6), PBS Only

IL-1 beta Monoclonal Antibody for Cytometric bead array, Indirect ELISA

Host / Isotype

Mouse / IgG1

Reactivity

human

Applications

Cytometric bead array, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

2A7C6

Cat no : 65276-1-PBS

Synonyms

IL1- beta, IL1 beta, IL 1 beta, IL 1, Catabolin

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Validation Data Gallery

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  Cytometric bead array standard curve of MP80001-1

  Cytometric bead array standard curve of MP80001-1, IL-1 beta Hybrid Matched Antibody Pair, PBS Only. Capture antibody: 82696-6-PBS. Detection antibody: 65276-1-PBS. Standard:HZ-1164. Range: 6.25-100 ng/mL.

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  Cytometric bead array standard curve of MP80001-5

  Cytometric bead array standard curve of MP80001-5, IL-1 beta Hybrid Matched Antibody Pair, PBS Only. Capture antibody: 82696-3-RR. Detection antibody: 65276-1-PBS. Standard:HZ-1164. Range: 3.125-100 ng/mL.

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Product Information

65276-1-PBS targets IL-1 beta as part of a matched antibody pair:

MP80001-1: 82696-6-PBS capture and 65276-1-PBS detection (validated in Cytometric bead array)

MP80001-5: 82696-3-PBS capture and 65276-1-PBS detection (validated in Cytometric bead array)

Unconjugated mouse monoclonal antibody pair in PBS only (BSA and azide free) storage buffer at a concentration of 1 mg/mL, ready for conjugation.

This conjugation ready format makes antibodies ideal for use in many applications including: ELISAs, multiplex assays requiring matched pairs, mass cytometry, and multiplex imaging applications.Antibody use should be optimized by the end user for each application and assay.

• Tested Reactivity: human
• Host / Isotype: Mouse / IgG1
• Class: Monoclonal
• Type: Antibody
• Immunogen: IL-1 beta fusion protein HZ-1164
• Full Name: interleukin 1, beta
• Calculated Molecular Weight: 269 aa, 31 kDa
• GenBank Accession Number: BC008678
• Gene Symbol: IL1B
• Gene ID (NCBI): 3553
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Affinity purification
• Storage Buffer: PBS Only
• Storage Conditions: Store at -80°C.

Background Information

Interleukin-1 is a pro-inflammatory cytokine with multiple biological effects. The IL-1 gene family encodes three proteins: IL-1α, IL-1β and their naturally occurring inhibitor Il-1RN. Interleukin 1β (IL-1β), mainly produced by blood monocytes and tissue macrophages, has been implicated in mediating both acute and chronic inflammation. IL-1β is known to be involved in a variety of cellular activities, including cell proliferation, differentiation and apoptosis. IL-1β is emerging as a key mediator of carcinogenesis that characterizes host-environment interactions. (PMID: 8630372; 12401481; 23704929; 24618930)