IHCeasy RPL23 Ready-To-Use IHC Kit
RPL23 Ready-to-use reagent kit for IHC.
Cat no : KHC0639
60S ribosomal protein L17, 60S ribosomal protein L23, ribosomal protein L23, rpL17, RPL23
KHC0639 is a ready-to-use IHC kit for staining of RPL23. The kit provides all reagents, from antigen retrieval to cover slip mounting, that require little to no diluting or handling prior to use. Simply apply the reagents to your sample slide according to the protocol and you're steps away from obtaining high-quality IHC data.
|IHCeasy RPL23 Ready-To-Use IHC Kit
|Primary antibody type
|Secondary antibody type
|Antigen Retrieval Buffer
|100 mL ×2
|Chromogen Component A
|Chromogen Component B
|Counter Staining Reagent
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. RPL23 is a component of the 60 S large ribosomal subunit that interacts functionally with murine double minute 2 protein (MDM2 or HDM2 in humans). Upon binding to MDM2, RPL23 inhibits MDM2-mediated p53 degradation, thus activating p53 and inducing cellular apoptosi. Intriguingly, RPL23 has also been suggested to be a negative regulator of apoptosis by suppressing the Miz1-induced transcription of the cell cycle inhibitors p15INK4B and p21CIP1.
|All the reagents are stored at 2-8°C. The kit is stable for 6 months from the date of receipt.
|60S ribosomal protein L17, 60S ribosomal protein L23, ribosomal protein L23, rpL17, RPL23