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Anti-Human IFNAR1 Rabbit Recombinant Antibody, PBS Only

IFNAR1 Uni-rAbTM Recombinant Antibody for FC

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

FC

Conjugate

Unconjugated

CloneNo.

230549B1

Cat no : 98067-1-PBS

Synonyms

IFN alpha REC, Cytokine receptor class-II member 1, CRF2-1, CRF2 1, AVP

Validation Data Gallery

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  • Flow cytometry (FC) experiment of U-937 cells using Anti-Human IFNAR1 Rabbit Recombinant Antibody (98067-1-RR)

    FC experiment of U-937 using 98067-1-RR (same clone as 98067-1-PBS)

    1x10^6 U-937 cells were surface stained with 0.25 ug Anti-Human IFNAR1 Rabbit Recombinant Antibody (98067-1-RR, Clone:230549B1) and PE-Conjugated Goat Anti-Rabbit IgG(H+L)(red), or 0.25 ug Isotype Control (blue). Cells were not fixed. This data was developed using the same antibody clone with 98067-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 98067-1-RR

    Affinity and Kinetic Characterization of 98067-1-RR

    Biolayer interferometry (BLl) kinetic assays of 98067-1-RR against Human IFNAR1 were performed. The affinity constant is 1.15 nM.

Product Information

The immunogen of 98067-1-PBS is IFNAR1 Fusion Protein expressed in E. coli.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen Fusion Protein
Full Name interferon (alpha, beta and omega) receptor 1
Calculated Molecular Weight 557 aa, 64 kDa
GenBank Accession NumberBC021825
Gene Symbol IFNAR1
Gene ID (NCBI) 3454
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

Interferon alpha and beta receptor subunit 1 (IFNAR1) is a type I membrane protein that associates with IFNAR2 to form the receptor for type I interferons, including interferons-alpha, -beta, and -lambda. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2, and then increase transcription of the IFN-induced genes whose products exert antiviral, immunomodulatory, and antiproliferative effects.