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IDS Recombinant antibody, PBS Only

IDS Uni-rAbTM Recombinant Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

242054A7

Cat no : 84623-6-PBS

Synonyms

Iduronate 2-sulfatase 42 kDa chain, Iduronate 2-sulfatase 14 kDa chain, Iduronate 2-sulfatase, EC:3.1.6.13, Alpha-L-iduronate sulfate sulfatase

Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using IDS Recombinant antibody (84623-6-RR)

    WB analysis using 84623-6-RR (same clone as 84623-6-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 84623-6-RR (IDS antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84623-6-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84623-6-RR

    Affinity and Kinetic Characterization of 84623-6-RR

    Biolayer interferometry (BLl) kinetic assays of 84623-6-RR against Human IDS were performed. The affinity constant is 11.8 nM.

Product Information

84623-6-PBS targets IDS in WB, Indirect ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen IDS fusion protein Ag31132
Full Name iduronate 2-sulfatase
Calculated Molecular Weight312aa,35 kDa; 550aa,62 kDa
Observed Molecular Weight42 kDa
GenBank Accession NumberBC006170
Gene Symbol IDS
Gene ID (NCBI) 3423
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

Iduronate 2-sulfatase (IDS) is required for the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations causing IDS deficiency in humans result in the lysosomal storage of these glycosaminoglycans and Hunter syndrome, an X chromosome-linked disease. IDS is synthesized as two precursor forms of 76 and 90 kDa that are converted, through a 62 kDa intermediate, to mature polypeptides due to an internal proteolytic cleavage (PMID: 10838181).