Anti-Human ICOS/CD278 Rabbit Recombinant Antibody, PBS Only

ICOS/CD278 Uni-rAb^TM Recombinant Antibody for FC

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

FC

Conjugate

Unconjugated

CloneNo.

241770G11

Cat no : 98214-1-PBS

Synonyms

ICOS, CVID1, CD278, AILIM, Activation-inducible lymphocyte immunomediatory molecule

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Validation Data Gallery

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  FC experiment of human PBMCs using 98214-1-RR (same clone as 98214-1-PBS)

  1x10^6 untreated or PHA treated human PBMCs were surface stained with 0.25 ug Anti-Human ICOS/CD278 Rabbit Recombinant Antibody (98214-1-RR, Clone: 241770G11) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were co-stained with APC Anti-Human CD3 (OKT3) Mouse IgG2a Recombinant Antibody (APC-65569, Clone: OKT3). Cells were not fixed. This data was developed using the same antibody clone with 98214-1-PBS in a different storage buffer formulation.

• 

  FC experiment of human PBMCs using 98214-1-RR (same clone as 98214-1-PBS)

  1x10^6 PHA treated human PBMCs were surface stained with 0.25 ug Anti-Human ICOS/CD278 Rabbit Recombinant Antibody (98214-1-RR, Clone: 241770G11) (red) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). 1x10^6 untreated human PBMCs were surface stained with 0.25 ug Anti-Human ICOS/CD278 Rabbit Recombinant Antibody (98214-1-RR, Clone: 241770G11) (black, dashed). Cells were not fixed. This data was developed using the same antibody clone with 98214-1-PBS in a different storage buffer formulation.

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Product Information

98214-1-PBS targets ICOS/CD278 in FC applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen: Recombinant protein
• Full Name: inducible T-cell co-stimulator
• Calculated Molecular Weight: 199 aa, 23 kDa
• GenBank Accession Number: BC028210
• Gene Symbol: ICOS
• Gene ID (NCBI): 29851
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purfication
• Storage Buffer: PBS Only
• Storage Conditions: Store at -80°C.

Background Information

Inducible T cell co-stimulator (ICOS) is related to the CD28 superfamily and is highly expressed on activated T cells as well as regulatory T cells and is crucial for the survival and function of T cells, Th2 cell differentiation, and lung inflammatory responses. Binding ICOS to ICOS-ligand (ICOS-L) activates a cascade of intracellular signaling molecules that prevent apoptosis and lead to the production of cytokines such as IL-4 and IL-13.