Product Information
67488-1-PBS targets HRD1/SYVN1 in WB, IHC, IF/ICC, ELISA applications and shows reactivity with human, mouse, rat samples.
Tested Reactivity | human, mouse, rat |
Host / Isotype | Mouse / IgG2b |
Class | Monoclonal |
Type | Antibody |
Immunogen | HRD1/SYVN1 fusion protein Ag4456 Predict reactive species |
Full Name | synovial apoptosis inhibitor 1, synoviolin |
Calculated Molecular Weight | 617 aa, 68 kDa |
Observed Molecular Weight | 68-76 kDa |
GenBank Accession Number | BC030530 |
Gene Symbol | HRD1 |
Gene ID (NCBI) | 84447 |
RRID | AB_2882714 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
UNIPROT ID | Q86TM6 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
HRD1is also named as SYVN1(Synovial apoptosis inhibitor 1) , KIAA1810. It acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Two distinct binding sites mediate Hrd1 dimerization or oligomerization, one located within the transmembrane region and another within the cytosolic domain. (PMID:19864457).Western blot analysis detected abundant HRD1 expression in liver and kidney. Mouse liver and spleen expressed Hrd1 as an 85-kD protein(PMID:12646171).