HMMR Monoclonal antibody, PBS Only

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  WB analysis using 68718-1-Ig (same clone as 68718-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 68718-1-Ig (HMMR antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68718-1-PBS in a different storage buffer formulation.

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  IF Staining of HepG2 using 68718-1-Ig (same clone as 68718-1-PBS)

  Immunofluorescent analysis of (-20°C Ethanol) fixed HepG2 cells using HMMR antibody (68718-1-Ig, Clone: 1C6B5 ) at dilution of 1:800 and Multi-rAb CoraLite ® Plus 488-Goat Anti-Mouse Recombinant Secondary Antibody (H+L) (RGAM002). This data was developed using the same antibody clone with 68718-1-PBS in a different storage buffer formulation.

HMMR Monoclonal Antibody for WB, IF/ICC, Indirect ELISA

Cat No. 68718-1-PBS

Clone No.1C6B5

Host / Isotype

Mouse / IgG1

Reactivity

human

Applications

WB, IF/ICC, Indirect ELISA

Synonyms

RHAMM, Receptor for hyaluronan-mediated motility, Intracellular hyaluronic acid-binding protein, IHABP, CD168

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Product Information

68718-1-PBS targets HMMR in WB, IF/ICC, Indirect ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Mouse / IgG1
• Class: Monoclonal
• Type: Antibody
• Immunogen: HMMR fusion protein Ag33723
• Full Name: hyaluronan-mediated motility receptor (RHAMM)
• Calculated Molecular Weight: 84 kDa
• Observed Molecular Weight: 84 kDa
• GenBank Accession Number: NM_012484
• Gene Symbol: HMMR
• Gene ID (NCBI): 3161
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein G purification
• UNIPROT ID: O75330
• Storage Buffer: PBS Only
• Storage Conditions: Store at -80°C.

Background Information

Hyaluronan-mediated motility receptor (HMMR), also termed CD168, was first described by Turley in murine cells . It is reported that HMMR has an extensive coiled-coil structure (CC) that contains multiple sites for interactive partners. Initially, HMMR was considered a novel hyaluronan-mediated motility receptor and a microtubule-associated spindle assembly factor. Full-length human RHAMM is an 85  kDa coiled-coil protein that occurs both in intracellular and extracellular compartments. It has highly restricted and tightly regulated expression in most normal tissues, but is one of a number of oncogenic proteins that are exported to the cell surface in response to tissue stress by unconventional transport mechanisms. (PMID: 36750558, PMID: 30249497)