Product Information
66557-1-PBS targets HE4 as part of a matched antibody pair:
MP51083-2: 66557-1-PBS capture and 66557-3-PBS detection (validated in Cytometric bead array)
Unconjugated mouse monoclonal antibody pair in PBS only (BSA and azide free) storage buffer at a concentration of 1 mg/mL, ready for conjugation.
This conjugation ready format makes antibodies ideal for use in many applications including: ELISAs, multiplex assays requiring matched pairs, mass cytometry, and multiplex imaging applications.Antibody use should be optimized by the end user for each application and assay.
| Tested Reactivity | human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Immunogen | HE4 fusion protein Ag5936 Predict reactive species |
| Full Name | WAP four-disulfide core domain 2 |
| Calculated Molecular Weight | 13 kDa |
| GenBank Accession Number | BC046106 |
| Gene Symbol | HE4 |
| Gene ID (NCBI) | 10406 |
| RRID | AB_2881918 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein G purification |
| UNIPROT ID | Q14508 |
| Storage Buffer | PBS Only |
| Storage Conditions | Store at -80°C. |
Background Information
WFDC2, also named as HE4, is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. HE4 is expressed in a number of normal tissues, and it is also highly expressed in a number of tumors cells lines, such ovarian, colon, breast, lung and renal cells lines. In some study, HE4 was referred to as a biomarker for ovarian carcinoma.
