- Featured Product
- KD/KO Validated
GLI1 Monoclonal antibody, PBS Only
GLI1 Monoclonal Antibody for WB, IF/ICC, ELISA
Host / Isotype
Mouse / IgG1
Reactivity
Human, rat, mouse, pig
Applications
WB, IF/ICC, ELISA
Conjugate
Unconjugated
CloneNo.
1D2B2
Cat no : 66905-1-PBS
Synonyms
Validation Data Gallery
Product Information
66905-1-PBS targets GLI1 in WB, IF/ICC, ELISA applications and shows reactivity with Human, rat, mouse, pig samples.
Tested Reactivity | Human, rat, mouse, pig |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Immunogen | GLI1 fusion protein Ag27832 |
Full Name | GLI family zinc finger 1 |
Calculated Molecular Weight | 1106 aa, 118 kDa |
Observed Molecular Weight | 150 kDa |
GenBank Accession Number | BC013000 |
Gene Symbol | GLI1 |
Gene ID (NCBI) | 2735 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
Storage Buffer | PBS only |
Storage Conditions | Store at -80°C. |
Background Information
GLI1, also known as Glioma-associated oncogene, is a 1106 amino acid protein, which belongs to the GLI C2H2-type zinc-finger protein family. GLI1 is detected in testis and Also expressed in the brain with highest expression in the cerebellum, optic nerve and olfactory tract. GLI1 is tethered in the cytoplasm by binding to SUFU (PubMed:10806483). GLI1 is activated and translocated to the nucleus promoted by interaction with STK36 (PubMed:10806483). Phosphorylation of GLI1 by ULK3 may promote nuclear localization (PubMed:19878745). GLI1 as a transcriptional activator may regulate the transcription of specific genes during normal development (PubMed:19706761). GLI1 plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract and Mediates SHH signaling (PubMed:19706761). GLI1 plays a role in cell proliferation and differentiation via its role in SHH signaling.