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GDF10 Monoclonal antibody, PBS Only

GDF10 Monoclonal Antibody for WB, Indirect ELISA

Host / Isotype

Mouse / IgG2a

Reactivity

human, pig, rat

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

1B7D12

Cat no : 66371-1-PBS

Synonyms

BIP, BMP 3b, BMP3B, Bone inducing protein, Bone morphogenetic protein 3B, GDF 10, GDF10

Validation Data Gallery

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  • Western Blot (WB) analysis of pig bone marrow tissue using GDF10 Monoclonal antibody (66371-1-Ig)

    WB analysis of pig bone marrow using 66371-1-Ig (same clone as 66371-1-PBS)

    pig bone marrow tissue were subjected to SDS PAGE followed by western blot with 66371-1-Ig (GDF10 Antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66371-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of ROS1728 cells using GDF10 Monoclonal antibody (66371-1-Ig)

    WB analysis of ROS1728 using 66371-1-Ig (same clone as 66371-1-PBS)

    ROS1728 cells were subjected to SDS PAGE followed by western blot with 66371-1-Ig (GDF10 Antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66371-1-PBS in a different storage buffer formulation.

Product Information

66371-1-PBS targets GDF10 in WB, Indirect ELISA applications and shows reactivity with human, pig, rat samples.

Tested Reactivity human, pig, rat
Host / Isotype Mouse / IgG2a
Class Monoclonal
Type Antibody
Immunogen GDF10 fusion protein Ag4906
Full Name growth differentiation factor 10
Calculated Molecular Weight 53 kDa
Observed Molecular Weight 53 kDa
GenBank Accession NumberBC028237
Gene Symbol GDF10
Gene ID (NCBI) 2662
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

Growth differentiation factor-10 (GDF10), also known as BMP3b, is a member of the transforming growth factor-b (TGF-b) superfamily. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This promotes neural repair after stroke. GDF10 plays a role in head formation and may have multiple roles in skeletal morphogenesis. Additionally, GDF10 may act as a tumor suppressor and reduced expression of this gene is associated with oral cancer.