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Fibrinogen Beta Chain Monoclonal antibody, PBS Only

Fibrinogen Beta Chain Monoclonal Antibody for WB, Indirect ELISA

Host / Isotype

Mouse / IgG2b

Reactivity

human

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

1F8E4

Cat no : 66186-1-PBS

Synonyms

FGB, fibrinogen beta chain

Validation Data Gallery

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  • Western Blot (WB) analysis of human heart tissue using Fibrinogen Beta Chain Monoclonal antibody (66186-1-Ig)

    WB analysis of human heart using 66186-1-Ig (same clone as 66186-1-PBS)

    human heart tissue were subjected to SDS PAGE followed by western blot with 66186-1-Ig (Fibrinogen beta chain antibody at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66186-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of fetal human brain tissue using Fibrinogen Beta Chain Monoclonal antibody (66186-1-Ig)

    WB analysis of fetal human brain using 66186-1-Ig (same clone as 66186-1-PBS)

    fetal human brain tissue were subjected to SDS PAGE followed by western blot with 66186-1-Ig (Fibrinogen beta chain antibody at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66186-1-PBS in a different storage buffer formulation.

Product Information

66186-1-PBS targets Fibrinogen Beta Chain in WB, Indirect ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Mouse / IgG2b
Class Monoclonal
Type Antibody
Immunogen Fibrinogen Beta Chain fusion protein Ag10205
Full Name fibrinogen beta chain
Calculated Molecular Weight 491 aa, 56 kDa
Observed Molecular Weight 50 kDa
GenBank Accession NumberBC107766
Gene Symbol Fibrinogen Beta Chain
Gene ID (NCBI) 2244
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

Fibrinogen is a soluble plasma glycoprotein synthesized in the liver. It is composed of two sets of three structurally different subunits: alpha (FGA), beta (FGB), gamma (FGG). Fibrinogen is converted by thrombin into fibrin during blood coagulation. Fibrinogen and fibrin play overlapping roles in blood clotting, fibrinolysis, cellular and matrix interactions, the inflammatory response, wound healing, and neoplasia (PMID: 16102057). FGB is the beta chain of fibrinogen. During conversion of fibrinogen to fibrin, fibrinopeptide B is cleaved from FGB by thrombin. Mutations in the gene of FGB lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency.