Product Information
80793-1-PBS targets Fetuin-A/AHSG in WB, Indirect ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Recombinant |
| Type | Antibody |
| Immunogen | Fetuin-A/AHSG fusion protein Ag9853 Predict reactive species |
| Full Name | alpha-2-HS-glycoprotein |
| Calculated Molecular Weight | 367 aa, 39 kDa |
| Observed Molecular Weight | 58 kDa |
| GenBank Accession Number | BC048198 |
| Gene Symbol | Fetuin-A |
| Gene ID (NCBI) | 197 |
| RRID | AB_2918913 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein A purification |
| UNIPROT ID | P02765 |
| Storage Buffer | PBS Only |
| Storage Conditions | Store at -80°C. |
Background Information
Fetuin-A, also named as Alpha2-HS glycoprotein (AHSG), is a member of cystatin superfamily of protease inhibitors. It is a highly expressed glycoprotein in various fetal tissues whereas it is mainly expressed by the liver in adults. Fetuin A, an extracellular inhibitor of transforming growth factor β, is a profibrogenic stimulus in liver disease. Circulating fetuin-A may be a beneficial serum biomarker in the detection of liver and vascular fibrosis progression in patients with non-alcoholic fatty liver disease. It is also involved in several functions, such as endocytosis, brain development and the formation of bone tissue. Fetuin-A exerts its effects on the cardiovascular system by two different mechanisms. On the one hand it inhibits ins signaling and induces ins resistance contributing to the onset of atherosclerosis and on the other hand it inhibits calcium deposition and protects from vascular calcification.
