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Fetuin-A/AHSG Recombinant antibody, PBS Only

Fetuin-A/AHSG Uni-rAbTM Recombinant Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

1E4

Cat no : 80793-1-PBS

Synonyms

AHSG, Fetuin-A, Alpha 2 Z globulin, alpha 2 HS glycoprotein, AHS

Validation Data Gallery

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  • Western Blot (WB) analysis of human plasma using Fetuin-A/AHSG Recombinant antibody (80793-1-RR)

    WB analysis of human plasma using 80793-1-RR (same clone as 80793-1-PBS)

    human plasma were subjected to SDS PAGE followed by western blot with 80793-1-RR (Fetuin-A antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 80793-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 80793-1-RR

    Affinity and Kinetic Characterization of 80793-1-RR

    Biolayer interferometry (BLl) kinetic assays of 80793-1-RR against Human AHSG were performed. The affinity constant is 5.52 nM.

Product Information

80793-1-PBS targets Fetuin-A/AHSG in WB, Indirect ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen Fetuin-A/AHSG fusion protein Ag9853
Full Name alpha-2-HS-glycoprotein
Calculated Molecular Weight 367 aa, 39 kDa
Observed Molecular Weight58 kDa
GenBank Accession NumberBC048198
Gene Symbol Fetuin-A
Gene ID (NCBI) 197
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

Fetuin-A, also named as Alpha2-HS glycoprotein (AHSG), is a member of cystatin superfamily of protease inhibitors. It is a highly expressed glycoprotein in various fetal tissues whereas it is mainly expressed by the liver in adults. Fetuin A, an extracellular inhibitor of transforming growth factor β, is a profibrogenic stimulus in liver disease. Circulating fetuin-A may be a beneficial serum biomarker in the detection of liver and vascular fibrosis progression in patients with non-alcoholic fatty liver disease. It is also involved in several functions, such as endocytosis, brain development and the formation of bone tissue. Fetuin-A exerts its effects on the cardiovascular system by two different mechanisms. On the one hand it inhibits ins signaling and induces ins resistance contributing to the onset of atherosclerosis and on the other hand it inhibits calcium deposition and protects from vascular calcification.