Anti-Mouse Fas/CD95 Rabbit Recombinant Antibody, PBS Only

Fas/CD95 Uni-rAb^TM Recombinant Antibody for FC

Host / Isotype

Rabbit / IgG

Reactivity

mouse

Applications

FC

Conjugate

Unconjugated

CloneNo.

241229C11

Cat no : 98135-1-PBS

Synonyms

Fas, CD95, TNFR6, APT1, APO 1

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Validation Data Gallery

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  FC experiment of mouse thymocytes using 98135-1-RR (same clone as 98135-1-PBS)

  1x10^6 mouse thymocytes were surface stained with 0.25 ug Anti-Mouse Fas/CD95 Rabbit Recombinant Antibody (98135-1-RR, Clone: 241229C11) or Isotype Control, and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were then stained with APC Anti-Mouse CD8a (53-6.7) (APC-65069, Clone: 53-6.7). Cells were not fixed. This data was developed using the same antibody clone with 98135-1-PBS in a different storage buffer formulation.

• 

  FC experiment of mouse thymocytes using 98135-1-RR (same clone as 98135-1-PBS)

  1x10^6 mouse thymocytes were surface stained with 0.25 ug Anti-Mouse Fas/CD95 Rabbit Recombinant Antibody (98135-1-RR, Clone: 241229C11) (red) or Isotype Control (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98135-1-PBS in a different storage buffer formulation.

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Product Information

98135-1-PBS targets Fas/CD95 in FC applications and shows reactivity with mouse samples.

• Tested Reactivity: mouse
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen: FusionProtein
• Full Name: Fas (TNF receptor superfamily member 6)
• Calculated Molecular Weight: 37kDa
• GenBank Accession Number: NM_007987.2
• Gene Symbol: Fas/CD95
• Gene ID (NCBI): 14102
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purfication
• Storage Buffer: PBS Only
• Storage Conditions: Store at -80°C.

Background Information

Fas (CD95/APO-1) is a transmembrane glycoprotein belonging to the tumor necrosis factor (TNF) receptor superfamily. It can mediate apoptosis by ligation with an agonistic anti-Fas antibody or Fas ligand. Stimulation of Fas results in the aggregation of its intracellular death domains, leading to the formation of the death-inducing signaling complex (DISC). FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The molecular mass of native Fas is 38 kDa, the high molecular weight form (40-55 kDa) of Fas is due to glycosylation.