Anti-Human FGFR2/CD332 Rabbit Recombinant Antibody

FGFR2/CD332 Uni-rAb^TM Recombinant Antibody for FC

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

FC

Conjugate

Unconjugated

CloneNo.

241383D11

Cat no : 98244-1-RR

Synonyms

FGFR2, CFD1, CEK3, CD332, BFR 1

---

Validation Data Gallery

• 

  FC experiment of Transfected HEK-293T using 98244-1-RR

  1x10^6 HEK-293T cells or FGFR2/CD332 transfected HEK-293T cells were surface stained with 0.25 ug Anti-Human FGFR2/CD332 Rabbit Recombinant Antibody (98244-1-RR, Clone: 241383D11) and Multi-rAb CoraLite ® Plus 647-Goat Anti-Rabbit Recombinant Secondary Antibody (H+L) (RGAR005). Cells were not fixed.

• 

  FC experiment of Transfected HEK-293T using 98244-1-RR

  1x10^6 HEK-293T cells (left) or FGFR2/CD332 transfected HEK-293T cells (right) were surface stained with 0.25 ug Anti-Human FGFR2/CD332 Rabbit Recombinant Antibody (98244-1-RR, Clone:241383D11) (red) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue), and Multi-rAb CoraLite ® Plus 647-Goat Anti-Rabbit Recombinant Secondary Antibody (H+L) (RGAR005). Cells were not fixed.

---

Tested Applications

• Positive FC detected in: Transfected HEK-293T cells

Recommended dilution

Application	Dilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

98244-1-RR targets FGFR2/CD332 in FC applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen: Recombinant protein
• Full Name: fibroblast growth factor receptor 2
• Calculated Molecular Weight: 92kd
• GenBank Accession Number: NM_000141.4
• Gene Symbol: FGFR2
• Gene ID (NCBI): 2263
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purfication
• Storage Buffer: PBS with 0.09% sodium azide, pH 7.3.
• Storage Conditions: Store at 2 - 8°C. Stable for one year after shipment.

Background Information

FGFR2 (Fibroblast growth factor receptor 2), also known as CD332, is a tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration, and apoptosis. Ligand binding leads to the activation of several signaling pathways, such as RAS, MAPK1/ERK2, MAPK3/ERK1, and the MAP Kinase signaling pathway, as well as the AKT1 signaling pathway. Mutations in the gene of FGFR2 are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis.