FBXO22 Monoclonal antibody, PBS Only

FBXO22 Monoclonal Antibody for WB, Indirect ELISA

Host / Isotype

Mouse / IgG1

Reactivity

Human

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

4B8A12

Cat no : 68650-1-PBS

Synonyms

F box only protein 22, F box protein 22, F box protein FBX22p44, FBX22, FBXO22, FISTC1, FLJ13986

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Validation Data Gallery

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  WB analysis using 68650-1-Ig (same clone as 68650-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 68650-1-Ig (FBXO22 antibody) at dilution of 1:20000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68650-1-PBS in a different storage buffer formulation.

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Product Information

68650-1-PBS targets FBXO22 in WB, Indirect ELISA applications and shows reactivity with Human samples.

• Tested Reactivity: Human
• Host / Isotype: Mouse / IgG1
• Class: Monoclonal
• Type: Antibody
• Immunogen: FBXO22 fusion protein Ag5294
• Full Name: F-box protein 22
• Calculated Molecular Weight: 403 aa, 45 kDa
• Observed Molecular Weight: 45 kDa
• GenBank Accession Number: BC039024
• Gene Symbol: FBXO22
• Gene ID (NCBI): 26263
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein G purification
• Storage Buffer: PBS Only
• Storage Conditions: Store at -80°C.

Background Information

FBXO22, also named as FBX22, is a substrate-recognition of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. FBXO22 is a key regulator of senescence induction through ubiquitylation of p53 for degradation. FBXO22 also acts as a molecular switch for the antagonistic and agonistic actions of selective estrogen receptor modulators (SERM) and determines the sensitivity of breast cancer to SERM by ubiquitylating KDM4B complexed with unliganded or SERMs‐bound estrogen receptor (ER). (PMID: 32536008, PMID: 32249768)