ESM1 Polyclonal antibody

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  WB analysis using 32079-1-AP

  HUVEC cells were subjected to SDS PAGE followed by western blot with 32079-1-AP (ESM1 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours.

ESM1 Polyclonal Antibody for WB, ELISA

Cat No. 32079-1-AP

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, ELISA

Synonyms

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Tested Applications

• Positive WB detected in: HUVEC cells

Recommended dilution

• Western Blot (WB): WB : 1:1000-1:4000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

32079-1-AP targets ESM1 in WB, ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: ESM1 fusion protein Ag36144
• Full Name: endothelial cell-specific molecule 1
• Calculated Molecular Weight: 184 aa, 20 kDa
• Observed Molecular Weight: 20 kDa
• GenBank Accession Number: BC011989
• Gene Symbol: ESM1
• Gene ID (NCBI): 11082
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity Purification
• UNIPROT ID: Q9NQ30
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

ESM1, also known as endothelial cell-specific molecule 1 or endocan, is a protein-coding gene that encodes a secreted protein. It is primarily expressed in endothelial cells of human lung and kidney tissues, and its expression is regulated by cytokines, suggesting a role in endothelium-dependent pathological disorders. ESM1 has been implicated in various diseases, including gastric cancer, hypertension, and cervical cancer. In cervical cancer, ESM1 is overexpressed and acts as an independent prognostic factor associated with poor clinical outcomes. It promotes carcinoma angiogenesis and cervical squamous cell carcinoma progression through the VEGF/ERK signaling pathway.