Anti-Mouse CD324 (E-cadherin) Rabbit Recombinant Antibody, PBS Only

CD324 (E-cadherin) Uni-rAbTM Recombinant Antibody for FC

Host / Isotype

Rabbit / IgG

Reactivity

mouse, canine

Applications

FC

Conjugate

Unconjugated

CloneNo.

241282C1

Cat no : 98140-1-PBS

Synonyms

E-cadherin, L CAM, Ecad, Cdh1, cadherin 1



Product Information

The immunogen of 98140-1-PBS is CD324 (E-cadherin) Fusion Protein expressed in E. coli.

Tested Reactivity mouse, canine
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen Fusion Protein
Full Name cadherin 1
Calculated Molecular Weight98kDa
GenBank Accession NumberNM_009864.3
Gene Symbol E-cadherin
Gene ID (NCBI) 12550
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

Cadherins are a family of transmembrane glycoproteins that mediate calcium-dependent cell-cell adhesion and play an important role in the maintenance of normal tissue architecture. E-cadherin (epithelial cadherin), also known as CD324, CDH1 (cadherin 1) or CAM 120/80, is a classical member of the cadherin superfamily which also include N-, P-, R-, and B-cadherins. E-cadherin is expressed on the cell surface in most epithelial tissues. The extracellular region of E-cadherin establishes calcium-dependent homophilic trans binding, providing specific interaction with adjacent cells, while the cytoplasmic domain is connected to the actin cytoskeleton through the interaction with p120-, α-, β-, and γ-catenin (plakoglobin). E-cadherin is important in the maintenance of the epithelial integrity, and is involved in mechanisms regulating proliferation, differentiation, and survival of epithelial cell. E-cadherin may also play a role in tumorigenesis. It is considered to be an invasion suppressor protein and its loss is an indicator of high tumor aggressiveness.