DYNC2H1 Polyclonal antibody, PBS Only

DYNC2H1 Polyclonal Antibody for WB, IHC, IF/ICC, Indirect ELISA
Cat No. 29758-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, IHC, IF/ICC, Indirect ELISA

Formulation:  PBS Only
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

Freight/Packing: -

Quantity

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Product Information

29758-1-PBS targets DYNC2H1 in WB, IHC, IF/ICC, Indirect ELISA applications and shows reactivity with human, mouse samples.

Tested Reactivity human, mouse
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen DYNC2H1 fusion protein Ag30707 Predict reactive species
Full Name dynein, cytoplasmic 2, heavy chain 1
Calculated Molecular Weight 493 kDa
Observed Molecular Weight493 kDa
GenBank Accession NumberNM_001377
Gene Symbol DYNC2H1
Gene ID (NCBI) 79659
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDQ8NCM8
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

DYNC2H1 (Cytoplasmic dynein 2 heavy chain 1) is involved in ciliary intraflagellar transport (IFT). DYNC2H1 drives retrograde transport of the IFT-A protein complex that regulates tip-to-base transport in cilia, involved in the generation and maintenance of cilia. DYNC2H1 variants or retina-predominant variants cause nonsyndromic retinal degeneration (PMID:32753734). DYNC2H1 mutations also cause asphyxiating thoracic dystrophy and short rib-polydactyly syndrome (PMID: 19442771). DYNC2H1 was localized to the basal bodies by immunofluorescence staining (PMID: 21552265, PMID: 26077881, PMID: 30320547).

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