ChromoTek CoraLite® Plus 647-conjugated LAG3 VHH
CL647-lt targets LAG3 in FC and IF applications and shows reactivity with Human samples.
Host/Type
Alpaca VHH
Reactivity
Human
Applications
FC, IF
Conjugate
CoraLite® Plus 647 Fluorescent Dye
Cat no : CL647-lt
Synonyms
Validation Data Gallery
Product Information
CL647-lt targets LAG3 in FC and IF applications and shows reactivity with Human samples.
Applications | FC, IF |
Reactivity | Human |
Conjugate | CoraLite® Plus 647 Fluorescent Dye |
Type | Nanobody |
Class | Recombinant |
Host | Alpaca |
Affinity | Picomolar range, below the assay limit (biolayer interferometry) |
Molecular Weight | 15.141 kDa |
Form | Liquid |
Excitation/Emission Maxima Wavelengths | 654 nm / 674 nm |
RRID | AB_3101918 |
Storage Buffer | 500 mM NaCl, 10 mM HEPES pH 7.0, 5 mM EDTA, 0.09% sodium azide |
Storage Condition | Store at -20°C; Shipped at ambient temperature. |
Background | LAG-3, also known as CD223, is an immune checkpoint molecule that regulates both T-cell activation and homeostasis. LAG-3 is expressed on activated T cells, NK cells, regulatory T cells, and plasmacytoid dendritic cells. It is a CD4-related molecule that binds MHC class II. LAG-3 plays an important role in modulating T cell expansion and function, and blockade of LAG-3 with monoclonal antibodies can augment T cell function. (PMID: 15634887; 21086108; 28783703) |
Documentation
SDS |
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SDS_Immuno-Oncology VHHs (grouped) |