Collagen Type I Monoclonal antibody, PBS Only
Collagen Type I Monoclonal Antibody for WB, Indirect ELISA
Host / Isotype
Mouse / IgG1
Reactivity
Human, pig, mouse, rat
Applications
WB, Indirect ELISA
Conjugate
Unconjugated
CloneNo.
3D5E8
Cat no : 66761-1-PBS
Synonyms
Validation Data Gallery
Product Information
66761-1-PBS targets Collagen Type I in WB, Indirect ELISA applications and shows reactivity with Human, pig, mouse, rat samples.
Tested Reactivity | Human, pig, mouse, rat |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Immunogen | Collagen Type I fusion protein Ag6281 |
Full Name | collagen, type I, alpha 2 |
Calculated Molecular Weight | 1366 aa, 130 kDa |
Observed Molecular Weight | 140 kDa, 70-80 kDa |
GenBank Accession Number | BC054498 |
Gene Symbol | COL1A2 |
Gene ID (NCBI) | 1278 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein G purification |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
Type I collagen, the major structural component of connective tissues such as skin, tendon and bone, is the most abundant and widely expressed collagen in humans (PMID: 7620364; 8645190; 9016532). Type I collagen is a heterotrimer comprising one alpha 2(I) and two alpha 1(I) chains which are encoded by the unlinked loci COL1A2 and COL1A1 respectively. Type I collagen has a molecular mass of about 250-300 kDa, while the alpha 2(I) chain has a molecular weight of about 100-140 kDa. Mutations in COL1A2 gene are associated with osteogenesis imperfecta, Ehlers-Danlos syndrome, idiopathic osteoporosis, and atypical Marfan syndrome.