Claudin 18 Monoclonal antibody, PBS Only

Claudin 18 Monoclonal Antibody for IP, IHC, Indirect ELISA

Host / Isotype

Mouse / IgG2a

Reactivity

human, mouse

Applications

IP, IHC, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

5G7F2

Cat no : 66167-1-PBS

Synonyms

claudin 18, CLDN18, SFTA5, SFTPJ

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Validation Data Gallery

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  IP experiment of mouse stomach using 66167-1-Ig (same clone as 66167-1-PBS)

  IP result of anti-Claudin 18 (IP:66167-1-Ig, 3ug; Detection:66167-1-Ig 1:300) with mouse stomach tissue lysate 4000ug. This data was developed using the same antibody clone with 66167-1-PBS in a different storage buffer formulation.

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  IHC staining of human stomach using 66167-1-Ig (same clone as 66167-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human stomach tissue slide using 66167-1-Ig (Claudin 18 antibody at dilution of 1:1000. This data was developed using the same antibody clone with 66167-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human stomach using 66167-1-Ig (same clone as 66167-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human stomach tissue slide using 66167-1-Ig (Claudin 18 antibody at dilution of 1:1000. This data was developed using the same antibody clone with 66167-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human pancreas cancer using 66167-1-Ig (same clone as 66167-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human pancreas cancer tissue slide using 66167-1-Ig (Claudin 18 antibody at dilution of 1:600 (under 10x lens). This data was developed using the same antibody clone with 66167-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human pancreas cancer using 66167-1-Ig (same clone as 66167-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human pancreas cancer tissue slide using 66167-1-Ig (Claudin 18 antibody at dilution of 1:600 (under 40x lens). This data was developed using the same antibody clone with 66167-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human ovary tumor using 66167-1-Ig (same clone as 66167-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human ovary tumor tissue slide using 66167-1-Ig (Claudin 18 antibody at dilution of 1:1000. This data was developed using the same antibody clone with 66167-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human ovary tumor using 66167-1-Ig (same clone as 66167-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human ovary tumor tissue slide using 66167-1-Ig (Claudin 18 antibody at dilution of 1:1000. This data was developed using the same antibody clone with 66167-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human stomach using 66167-1-Ig (same clone as 66167-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human stomach tissue slide using 66167-1-Ig (Claudin 18 antibody) at dilution of 1:600 (under 40x lens). This data was developed using the same antibody clone with 66167-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human stomach using 66167-1-Ig (same clone as 66167-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human stomach tissue slide using 66167-1-Ig (Claudin 18 antibody at dilution of 1:600 (under 10x lens). This data was developed using the same antibody clone with 66167-1-PBS in a different storage buffer formulation.

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Product Information

66167-1-PBS targets Claudin 18 in IP, IHC, Indirect ELISA applications and shows reactivity with human, mouse samples.

• Tested Reactivity: human, mouse
• Host / Isotype: Mouse / IgG2a
• Class: Monoclonal
• Type: Antibody
• Immunogen: Claudin 18 fusion protein Ag15517
• Full Name: claudin 18
• Calculated Molecular Weight: 261 aa, 28 kDa
• Observed Molecular Weight: 29 kDa
• GenBank Accession Number: BC146668
• Gene Symbol: CLDN18
• Gene ID (NCBI): 51208
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• Storage Buffer: PBS Only
• Storage Conditions: Store at -80°C.

Background Information

Claudin 18 (CLDN18) belongs to the large claudin family of proteins, which are tetraspan transmembrane proteins of tight junctions (PMID: 11585919; 18036336). Claudins exhibit specific patterns of expression in different tissues (PMID: 15447685). CLDN18 is specifically expressed in the stomach and lung. CLDN18 has two alternatively spliced variants, CLDN18.1 and CLDN18.2. CLDN18.2 is a highly selective gastric lineage marker that determines the gastric phenotype in a neoplastic condition, whereas CLDN18.1 is lung specific (PMID: 11585919; 21832145). Altered CLDN18 expression has been reported in various human malignancies, including gastric cancer, lung adenocarcinoma, and pancreatic neoplasm (PMID: 17459057; 22076167; 21832145). This antibody can recognize both CLDN18.1 and CLDN18.2.