Cathepsin D Recombinant antibody, PBS Only (Detector)
Cathepsin D Uni-rAbTM Recombinant Antibody for WB, FC (Intra), Cytometric bead array, Sandwich ELISA, Indirect ELISA, Sample test
Host / Isotype
Rabbit / IgG
Reactivity
human
Applications
WB, FC (Intra), Cytometric bead array, Sandwich ELISA, Indirect ELISA, Sample test
Conjugate
Unconjugated
CloneNo.
240775E7
Cat no : 83743-2-PBS
Synonyms
Validation Data Gallery
Product Information
83743-2-PBS targets Cathepsin D as part of a matched antibody pair:
MP00695-1: 83743-1-PBS capture and 83743-2-PBS detection (validated in Cytometric bead array)
MP00695-4: 83743-6-PBS capture and 83743-2-PBS detection (validated in Sandwich ELISA)
Unconjugated rabbit recombinant monoclonal antibody in PBS only (BSA and azide free) storage buffer at a concentration of 1 mg/mL, ready for conjugation. Created using Proteintech’s proprietary in-house recombinant technology. Recombinant production enables unrivalled batch-to-batch consistency, easy scale-up, and future security of supply.
This conjugation ready format makes antibodies ideal for use in many applications including: ELISAs, multiplex assays requiring matched pairs, mass cytometry, and multiplex imaging applications.Antibody use should be optimized by the end user for each application and assay.
Tested Reactivity | human |
Host / Isotype | Rabbit / IgG |
Class | Recombinant |
Type | Antibody |
Immunogen | Fusion Protein |
Full Name | cathepsin D |
Calculated Molecular Weight | 45kDa |
Observed Molecular Weight | 32 kDa, 48 kDa, 52 kDa |
GenBank Accession Number | NM_001909.5 |
Gene Symbol | Cathepsin D |
Gene ID (NCBI) | 1509 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
CTSD (Cathepsin D) also named CPSD, belongs to the peptidase A1 family. It is ubiquitously expressed and is involved in proteolytic degradation, cell invasion, and apoptosis. Human CTSD is synthesized as a 52-kDa precursor that is converted into an active 48-kDa single-chain intermediate in the endosomes, and then into a fully active mature form, composed of a 34-kDa heavy chain and a 14-kDa light chain, in the lysosomes. It is a lysosomal acid protease found in neutrophils and monocytes and involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease (PMID: 27114232, PMID: 30717773, PMID: 30051532).