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Cathepsin D Polyclonal antibody, PBS Only

Cathepsin D Polyclonal Antibody for WB, IHC, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, IHC, Indirect ELISA

Conjugate

Unconjugated

Cat no : 55021-1-PBS

Synonyms

Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using Cathepsin D Polyclonal antibody (55021-1-AP)

    WB analysis using 55021-1-AP (same clone as 55021-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 55021-1-AP (Cathepsin D antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 55021-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human liver tissue using Cathepsin D Polyclonal antibody (55021-1-AP)

    IHC staining of human liver using 55021-1-AP (same clone as 55021-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human liver tissue slide using 55021-1-AP (Cathepsin D antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 55021-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human liver tissue using Cathepsin D Polyclonal antibody (55021-1-AP)

    IHC staining of human liver using 55021-1-AP (same clone as 55021-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human liver tissue slide using 55021-1-AP (Cathepsin D antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 55021-1-PBS in a different storage buffer formulation.

Product Information

55021-1-PBS targets Cathepsin D in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse samples.

Tested Reactivity human, mouse
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen Peptide
Full Name cathepsin D
Calculated Molecular Weight 45 kDa
Observed Molecular Weight 32 kDa
GenBank Accession NumberNM_001909
Gene Symbol Cathepsin D
Gene ID (NCBI) 1509
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

CTSD (Cathepsin D) is also named as CPSD, belongs to the peptidase A1 family. It is ubiquitously expressed and is involved in proteolytic degradation, cell invasion, and apoptosis. Human CTSD is synthesized as a 52-kDa precursor that is converted into an active 48-kDa single-chain intermediate in the endosomes, and then into a fully active mature form, composed of a 34-kDa heavy chain and a 14-kDa light chain, in the lysosomes. It is a lysosomal acid protease found in neutrophils and monocytes and involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. (PMID: 27114232, PMID: 30717773, PMID: 30051532)