Cleaved Caspase 8/P18 Recombinant antibody, PBS Only

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  WB analysis using 85171-3-RR (same clone as 85171-3-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 85171-3-RR (Cleaved Caspase 8/P18 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85171-3-PBS in a different storage buffer formulation.

Cleaved Caspase 8/P18 {ptg:Brand} Recombinant Antibody for WB, Indirect ELISA

Cat No. 85171-3-PBS

Clone No.242445E5

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Synonyms

CASP8, Caspase 8, 242445E5, Apoptotic cysteine protease, Apoptotic protease Mch-5

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Product Information

85171-3-PBS targets Cleaved Caspase 8/P18 in WB, Indirect ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen: Peptide
• Full Name: caspase 8, apoptosis-related cysteine peptidase
• Calculated Molecular Weight: 538 aa, 62 kDa
• Observed Molecular Weight: 55 kDa, 18 kDa
• GenBank Accession Number: BC028223
• Gene Symbol: Caspase 8
• Gene ID (NCBI): 841
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• UNIPROT ID: Q14790
• Storage Buffer: PBS only , pH 7.3
• Storage Conditions: Store at -80°C.

Background Information

CASP8, also named as MCH5, MACH, FLICE, and CAP4, belongs to the peptidase C14A family. It may participate in the GZMB apoptotic pathways and functions as an upstream regulator in a-bisabolol-induced apoptosis. CASP8 catalyzes an essential intermediate step in the ubiquitination and proteasome-mediated degradation of IRF3(PMID:21816816 ). It may control diabetic embryopathy-associated apoptosis via regulation of the Bid-stimulated mitochondrion/caspase-9 pathway (PMID:19194987). This antibody recognize the cleaved caspase 8.