Collagen Type I Recombinant antibody, PBS Only
Collagen Type I Uni-rAbTM Recombinant Antibody for IHC, IF/ICC, ELISA
Host / Isotype
Rabbit / IgG
Reactivity
human, rat
Applications
IHC, IF/ICC, ELISA
Conjugate
Unconjugated
CloneNo.
240665F8
Cat no : 83752-5-PBS
Synonyms
Validation Data Gallery
Product Information
The immunogen of 83752-5-PBS is Collagen Type I Fusion Protein expressed in E. coli.
Tested Reactivity | human, rat |
Host / Isotype | Rabbit / IgG |
Class | Recombinant |
Type | Antibody |
Immunogen | Collagen Type I fusion protein Ag6281 |
Full Name | collagen, type I, alpha 2 |
Calculated Molecular Weight | 1366 aa, 130 kDa |
Observed Molecular Weight | 120-130 kDa |
GenBank Accession Number | BC054498 |
Gene Symbol | COL1A2 |
Gene ID (NCBI) | 1278 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purfication |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
Type I collagen, the major structural component of connective tissues such as skin, tendon and bone, is the most abundant and widely expressed collagen in humans (PMID: 7620364; 8645190; 9016532). Type I collagen is a heterotrimer comprising one alpha 2(I) and two alpha 1(I) chains which are encoded by the unlinked loci COL1A2 and COL1A1 respectively. Type I collagen has a molecular mass of about 250-300 kDa, while the alpha 2(I) chain has a molecular weight of about 100-140 kDa. Mutations in COL1A2 gene are associated with osteogenesis imperfecta, Ehlers-Danlos syndrome, idiopathic osteoporosis, and atypical Marfan syndrome. This antibody raised against 1017-1366 aa of human pro-alpha 2 chain of type l collagen can recognize collagen alpha 2(1) chain and C-terminal propeptide of pro-alpha 2(1) chain.