Anti-Human CD79b Rabbit Recombinant Antibody, PBS Only

CD79b Uni-rAb^TM Recombinant Antibody for FC

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

FC

Conjugate

Unconjugated

CloneNo.

241273B7

Cat no : 98075-1-PBS

Synonyms

IGB, Ig beta, B-cell-specific glycoprotein B29, B-cell antigen receptor complex-associated protein beta chain, B29

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Validation Data Gallery

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  FC experiment of human PBMCs using 98075-1-RR (same clone as 98075-1-PBS)

  1x10^6 human PBMCs were stained with CoraLite® Plus 647 Anti-Human CD19 (4G7) Mouse IgG2a Recombinant Antibody (CL647-65562, Clone: 4G7) and 0.25 ug Anti-Human CD79b Rabbit Recombinant Antibody (98075-1-RR, Clone:241273B7), or Isotype Control. Cells were not fixed. This data was developed using the same antibody clone with 98075-1-PBS in a different storage buffer formulation.

• 

  FC experiment of human PBMCs using 98075-1-RR (same clone as 98075-1-PBS)

  1x10^6 human PBMCs were stained with 0.25 ug Anti-Human CD79b Rabbit Recombinant Antibody (98075-1-RR, Clone:241273B7) (red), or Isotype Control(blue). Cells were not fixed. This data was developed using the same antibody clone with 98075-1-PBS in a different storage buffer formulation.

• 

  FC experiment of human PBMCs using 98075-1-RR (same clone as 98075-1-PBS)

  1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human CD79b Rabbit Recombinant Antibody (98075-1-RR, Clone:241273B7) and PE-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L), and 0.25 ug CoraLite® Plus 647 Anti-Human CD19 (4G7) Mouse IgG2a Recombinant Antibody (CL647-65562, Clone: 4G7), and 0.25 ug Isotype Control. Cells were not fixed. This data was developed using the same antibody clone with 98075-1-PBS in a different storage buffer formulation.

• 

  Affinity and Kinetic Characterization of 98075-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98075-1-RR against Human CD79b were performed. The affinity constant is 1.41 nM.

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Product Information

98075-1-PBS targets CD79b in FC applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen: Recombinant Protein
• Full Name: CD79b molecule, immunoglobulin-associated beta
• Calculated Molecular Weight: 229 aa, 26 kDa
• GenBank Accession Number: BC032651
• Gene Symbol: CD79B
• Gene ID (NCBI): 974
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purfication
• Storage Buffer: PBS Only
• Storage Conditions: Store at -80°C.

Background Information

CD79 molecule encompasses two transmembrane proteins, CD79a and CD79b, which form a disulfide-linked heterodimer and are members of the immunoglobulin (Ig) gene superfamily (PMID: 2033258; 1375264; 2304550). CD79b molecule (also known as B29, IGB, AGM6, and Igbeta) is expressed almost exclusively on B cells and B-cell neoplasms, influencing antigen internalization and increasing antigen presentation efficiency (PMID: 7552998). CD79b mutation could be a key biomarker for DLBCL disease progression (PMID: 36182550).