Anti-Human CD6 Rabbit Recombinant Antibody, PBS Only

CD6 Uni-rAb^TM Recombinant Antibody for FC

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

FC

Conjugate

Unconjugated

CloneNo.

241965C9

Cat no : 98223-1-PBS

Synonyms

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Validation Data Gallery

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  FC experiment of human PBMCs using 98223-1-RR (same clone as 98223-1-PBS)

  1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human CD6 Rabbit Recombinant Antibody (98223-1-RR, Clone: 241965C9) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were co-stained with APC Anti-Human CD3 (OKT3) Mouse IgG2a Recombinant Antibody (APC-65569, Clone: OKT3). Cells were not fixed. This data was developed using the same antibody clone with 98223-1-PBS in a different storage buffer formulation.

• 

  FC experiment of human PBMCs using 98223-1-RR (same clone as 98223-1-PBS)

  1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human CD6 Rabbit Recombinant Antibody (98223-1-RR, Clone: 241965C9) (red) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98223-1-PBS in a different storage buffer formulation.

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Product Information

98223-1-PBS targets CD6 in FC applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen: Recombinant protein
• Full Name: CD6 molecule
• GenBank Accession Number: BC033755
• Gene Symbol: CD6
• Gene ID (NCBI): 923
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purfication
• Storage Buffer: PBS Only
• Storage Conditions: Store at -80°C.

Background Information

CD6 is a type I transmembrane glycoprotein that belongs to the scavenger receptor cysteine-rich superfamily (PMID: 21880988). It is composed of an extracellular region, which consists of three tandem SRCR domains, a transmembrane region, and a cytoplasmic tail devoid of intrinsic catalytic activity but harboring several phosphorylatable residues suitable for intracellular signal transduction (PMID: 38139340; 23711376). CD6 is expressed by T cells, medullary thymocytes, a subset of B cells and NK cells, and in some cells of the brain (PMID: 1919444; 21178331). CD6 plays a role in lymphocyte activation, proliferation, and survival processes via interaction with its endogenous ligands.