Anti-Human CD41a (HIP8)

CD41a Monoclonal Antibody for FC

Host / Isotype

Mouse / IgG1, kappa

Reactivity

human, non-human primates

Applications

FC

Conjugate

Unconjugated

CloneNo.

HIP8

Cat no : 65173-1-Ig

Synonyms

GTA, GPIIb, GPalpha IIb, GP2B, CD41B

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Validation Data Gallery

• 

  FC experiment of human peripheral blood using 65173-1-Ig

  100 ul human platelet rich plasma (diluted 1:4 with PBS) was surface stained with 0.2 ug Anti-Human CD41a (65173-1-Ig, Clone:HIP8) or Mouse IgG1 Isotype Control (65124-1-Ig, Clone: MOPC-21) and Multi-rAb CoraLite ® Plus 647-Goat Anti-Mouse Recombinant Secondary Antibody (H+L) (RGAM005). Cells were not fixed.

• 

  FC experiment of human peripheral blood using 65173-1-Ig

  100 ul human platelet rich plasma (diluted 1:4 with PBS) was surface stained with 0.2 ug Anti-Human CD41a (65173-1-Ig, Clone:HIP8) or Mouse IgG1 Isotype Control (65124-1-Ig, Clone: MOPC-21) and Multi-rAb CoraLite ® Plus 647-Goat Anti-Mouse Recombinant Secondary Antibody (H+L) (RGAM005). Cells were not fixed.

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Tested Applications

• Positive FC detected in: human peripheral blood

Recommended dilution

Application	Dilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

65173-1-Ig targets CD41a in FC applications and shows reactivity with human, non-human primates samples.

• Tested Reactivity: human, non-human primates
• Host / Isotype: Mouse / IgG1, kappa
• Class: Monoclonal
• Type: Antibody
• Immunogen: N/A
• Full Name: integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
• GenBank Accession Number: BC117443
• Gene Symbol: CD41a
• Gene ID (NCBI): 3674
• RRID: AB_2881482
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Affinity purification
• Storage Buffer: PBS with 0.09% sodium azide.
• Storage Conditions: Store at 2-8°C. Stable for one year after shipment.

Background Information

The integrins are a superfamily of cell adhesion receptors that bind to extracellular matrix ligands, cell-surface ligands, and soluble ligands (PMID: 17543136). They are transmembrane αβ heterodimers and at least 24 distinct integrin heterodimers are formed by the combination of 18 α and eight β known subunits (PMID: 17543136; 20029421). In addition to mediating cell adhesion, integrins also play important roles in modulating signal transduction pathways that control cellular responses including migration, proliferation, differentiation, and apoptosis (PMID:19118207). Integrin alpha-IIb (ITGA2B, CD41) is expressed on platelets, megakaryocytes and some hematopoietic progenitor cells (PMID: 11934866).