Anti-Human CD41a (HIP8)

CD41a Monoclonal Antibody for FC

Host / Isotype

Mouse / Mouse IgG1

Reactivity

Non-human primates, Human

Applications

FC

Conjugate

Unconjugated

CloneNo.

HIP8

Cat no : 65173-1-Ig

Synonyms

CD41, CD41a, CD41B, GP2B, GPalpha IIb, GPIIb, GTA, HIP8, HPA3, Integrin alpha IIb, ITGA2B, ITGAB

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Validation Data Gallery

• 

  FC experiment of human peripheral blood platelets using 65173-1-Ig

  1X10^6 human peripheral blood platelets were surface stained with 0.40 ug Purified Anti-Human CD41a (65173-1-Ig, Clone:HIP8) (red) or 0.40 ug Mouse IgG1 Isotype Control (blue) and CoraLite®488-Conjugated Goat Anti-Mouse IgG(H+L) with dilution 1:1000. Cells were not fixed.

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Tested Applications

• Positive FC detected in: Human peripheral blood platelets

Recommended dilution

Application	Dilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

65173-1-Ig targets CD41a in FC applications and shows reactivity with Non-human primates, Human samples.

• Tested Reactivity: Non-human primates, Human
• Host / Isotype: Mouse / Mouse IgG1
• Class: Monoclonal
• Type: Antibody
• Immunogen: N/A
• Full Name: integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
• GenBank Accession Number: BC117443
• Gene Symbol: CD41a
• Gene ID (NCBI): 3674
• RRID: AB_2881482
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Purified by protein-A affinity chromatography
• Storage Buffer: PBS with 0.1% sodium azide.
• Storage Conditions: Store at 2-8°C.

Background Information

The integrins are a superfamily of cell adhesion receptors that bind to extracellular matrix ligands, cell-surface ligands, and soluble ligands (PMID: 17543136). They are transmembrane αβ heterodimers and at least 24 distinct integrin heterodimers are formed by the combination of 18 α and eight β known subunits (PMID: 17543136; 20029421). In addition to mediating cell adhesion, integrins also play important roles in modulating signal transduction pathways that control cellular responses including migration, proliferation, differentiation, and apoptosis (PMID:19118207). Integrin alpha-IIb (ITGA2B, CD41) is expressed on platelets, megakaryocytes and some hematopoietic progenitor cells (PMID: 11934866).