Anti-Human B7-H3/CD276 Rabbit Recombinant Antibody, PBS Only

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  FC experiment of human monocyte-derived immature dendritic cells using 98017-1-RR (same clone as 98017-1-PBS)

  1x10^6 human monocyte-derived immature dendritic cells were surface stained with 0.25 ug Anti-Human B7-H3/CD276 Rabbit Recombinant Antibody (98017-1-RR, Clone: 230305A10) (red) or 0.25 ug Isotype Control(blue) and PE-conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98017-1-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 98017-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98017-1-RR against Human B7-H3/CD276 were performed. The affinity constant is 0.203 nM.

B7-H3/CD276 Uni-rAb^TM Recombinant Antibody for FC

Cat No. 98017-1-PBS

Clone No.230305A10

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

FC

Synonyms

CD276, B7-H3, B7H3, B7 homolog 3, B7 H3

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Product Information

98017-1-PBS targets B7-H3/CD276 in FC applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen: Recombinant protein
• Full Name: CD276 molecule
• Calculated Molecular Weight: 57 kDa
• GenBank Accession Number: NM_001024736
• Gene Symbol: CD276
• Gene ID (NCBI): 80381
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purfication
• UNIPROT ID: Q5ZPR3
• Storage Buffer: PBS Only
• Storage Conditions: Store at -80°C.

Background Information

B7-H3 (CD276) is a type I transmembrane protein expressed on many tissues and cell types. B7-H3 is a 100-kDa glycoprotein that belongs to the B7 immunoregulatory family and participates in the regulation of T-cell-mediated immune response probably by functioning as both a T cell costimulator and coinhibitor (PMID: 25567370; 20696859). Overexpressed on a wide range of human solid cancers, B7-H3 has been implicated in cancer progression and metastasis and becomes an attractive target for cancer immunotherapy (PMID: 27208063).