Anti-Mouse CD200R1 Rabbit Recombinant Antibody

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  FC experiment of mouse bone marrow cells using 98155-1-RR

  1x10^6 mouse bone marrow cells were surface stained with 0.25 ug Anti-Mouse CD200R1 Rabbit Recombinant Antibody (98155-1-RR, Clone: 241453E7) or Isotype Control, and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed.

• 

  FC experiment of mouse bone marrow cells using 98155-1-RR

  1x10^6 mouse bone marrow cells were surface stained with 0.25 ug Anti-Mouse CD200R1 Rabbit Recombinant Antibody (98155-1-RR, Clone: 241453E7) (red) or Isotype Control (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed.

• 

  Affinity and Kinetic Characterization of 98155-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98155-1-RR against Mouse CD200R1 were performed. The affinity constant is 3.33 nM.

CD200R1 Recombinant Antibody for FC

Cat No. 98155-1-RR

Clone No.241453E7

Host / Isotype

Rabbit / IgG

Reactivity

mouse

Applications

FC

Synonyms

OX2R, Mox2r, CD200R, CD200 receptor 1, 241453E7

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Tested Applications

• Positive FC detected in: mouse bone marrow cells

Recommended dilution

Application	Dilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

98155-1-RR targets CD200R1 in FC applications and shows reactivity with mouse samples.

• Tested Reactivity: mouse
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen: Fusion Protein
• Full Name: CD200 receptor 1
• Calculated Molecular Weight: 36 kDa
• GenBank Accession Number: NM_021325.3
• Gene Symbol: Cd200r1
• Gene ID (NCBI): 57781
• RRID: AB_3672298
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purfication
• UNIPROT ID: Q9ES57
• Storage Buffer: PBS with 0.09% sodium azide , pH 7.3
• Storage Conditions: Store at 2 - 8°C. Stable for one year after shipment.

Background Information

Cell surface glycoprotein CD200 receptor 1 (CD200R1) is also called CD200R, CRTR2, MOX2R, and OX2R, and belongs to the CD200R family. CD200R1 is an inhibitory receptor for the CD200/OX2 cell surface glycoprotein. CD200R1 is highly glycosylated, containing ten potential N-glycosylation sites (PMID: 15187158). CD200R1 limits inflammation by inhibiting the expression of pro-inflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli. As an immune inhibitory molecule, CD200R1 binds to CD200, ultimately leading to the inhibition of classical activation of macrophages and microglia (PMID: 24588829).