|Positive FC detected in
|This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
|Sample-dependent, check data in validation data gallery
65181-1-Ig targets CD146 in FC applications and shows reactivity with Rabbit, Canine, Mouse, Human samples.
|Rabbit, Canine, Mouse, Human
|Host / Isotype
|Mouse / IgG1, kappa
|cultured human umbilical cells
|melanoma cell adhesion molecule
|Calculated molecular weight
|646 aa, 72 kDa
|GenBank accession number
|Gene ID (NCBI)
|Purified by protein-A affinity chromatography
|PBS with 0.09% sodium azide.
|Store at 2-8°C. Stable for one year after shipment.
CD146, also known as melanoma cell adhesion molecule (MCAM) or MUC18, originally identified as a biomarker of melanoma progression, is a transmembrane glycoprotein of 113-130 kDa, belonging to the immunoglobulin (Ig) superfamily (PMID: 8378324; 25993332). Structurally, it consists of five Ig domains, a transmembrane domain, and a cytoplasmic region. In normal adult tissue, CD146 is primarily expressed by vascular endothelium and smooth muscle. CD146 is a key cell adhesion protein in vascular endothelial cell activity and angiogenesis, and has been used as marker of circulating endothelium cells (CECs) (PMID: 19356677). In addition to the membrane-anchored form of CD146, a soluble form of CD146 (sCD146, 105 kDa) has also been found in human plasma and in the supernatant of cultured human endothelial cells (PMID: 9462829; 19229070; 16374253; 14597988).
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